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TranscriptomicsGenome-wide Binding Site Mapping of Retinoic Acid Receptors and Coregulators in Breast Cancer Cells
Retinoic acid (RA) triggers growth-suppressive effects in tumor cells and therefore RA and its synthetic analogs have great potential as anti-carcinogenic agents. RA effects are mediated by retinoic acid receptors (RARs), which regulate gene expression in an RA-dependent manner. To define the geneti...
ORGANISM(S): Homo sapiens 
2009-03-16 | E-GEOD-15244 | biostudies-arrayexpress
GenomicsHP1BP3, a chromatin retention factor for co-transcriptional microRNA processing
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-07-24 | E-GEOD-77856 | biostudies-arrayexpress
TranscriptomicsExpression profiling of VCaP prostate cancer cells with ERG knockdown or WP1130 treatment
Microarray studies was performed to analyze gene expression profiling in VCaP cells after ERG was silenced by two different siRNAs or VCaP cells were treated by WP1130. RNA samples, containing 3 replicates for each sample, were extracted from VCaP cells at 72 hours siERG post-transfection or 24 hour...
ORGANISM(S): Homo sapiens 
2014-03-03 | E-GEOD-53994 | biostudies-arrayexpress
TranscriptomicsA Chromatin Immunoprecipitation Approach Based on BAC Transgenesis
We have devised a technology that enables chromatin immunoprecipitation (ChIP) experiments in cultured human cells by circumventing both the laborious production of protein-specific antibodies and the optimization of crosslinking/immunoprecipitation conditions for each protein. Our approach utilizes...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-10845 | biostudies-arrayexpress
TranscriptomicsMetabolic regulation of cancer cell proliferation is mediated by reactive oxygen species
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-09-25 | E-GEOD-59736 | biostudies-arrayexpress
GenomicsHP1BP3, a chromatin retention factor for co-transcriptional microRNA processing (ChIP-Seq)
Identification and characterization of HP1BP3 (a human histone H1 homologue) as a novel chromatin retention factor essential for the co-transcriptional processing of pri-miRNA. We generated BAC transgenic cells at 80% confluency (~1x107) were cross-linked with 1% formaldehyde for 10 minutes at 37°C...
ORGANISM(S): Homo sapiens 
2016-07-24 | E-GEOD-77854 | biostudies-arrayexpress
TranscriptomicsHP1BP3, a chromatin retention factor for co-transcriptional microRNA processing (miRNA-Seq)
Identification and characterization of HP1BP3 (a human histone H1 homologue) as a novel chromatin retention factor essential for the co-transcriptional processing of pri-miRNA. Compare global miRNA expression profile between control sample and sample depleted of HP1BP3
ORGANISM(S): Homo sapiens 
2016-07-24 | E-GEOD-77855 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of MCF7 with with the following NR ligands: estradiol/E2 (ERα agonist), AM580 (RARA agonist), CD437 (RARG agonist), ATRA (RARA/RARG agonist), GW0742 (PPARD agonist), R5020 (PGR agonist), and dexamethasone (GR/NR3C1 agonist).
Altered gene expression patterns in human diseases reflect perturbations in the transcriptional networks that regulate cellular state. In breast cancer, Nuclear Receptors (NRs) play a prominent role in governing gene expression. NRs have prognostic utility and are therapeutically important targets. ...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-42619 | biostudies-arrayexpress
TranscriptomicsEffect of pioglitazone treatment on gene expression in NCI-H2347 lung cancer cells: time course experiment
Microarray studies was performed to analyze gene expression changes in NCI-H2347 cells after treatment with 50 µM pioglitazone for 12hr, 24hr and 48hrs. RNA samples, containing 3 replicates for each sample, were extracted from NCI-H2347 cells after treatment with pioglitazone or vhicle (DMSO) for...
ORGANISM(S): Homo sapiens 
2014-09-25 | E-GEOD-59735 | biostudies-arrayexpress
TranscriptomicsGenome-scale RNAi profiling of cell division in human tissue culture cells
Cell division is a fundamental process for multicellula organisation. Here we report a genome-scale RNAi screen in HeLa cells designed to identify human genes important for cell division. We utilized a library of endoribonuclease-prepared siRNAs (esiRNAs) for gene-silencing and used DNA content an...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-9176 | biostudies-arrayexpress
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