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ProteomicsFilling the gaps – a call for comprehensive analysis of extracellular matrix of the glial scar in region- and injury-specific contexts
CNS injury results in chronic scar formation that interferes with function and inhibits repair. Extracellular matrix (ECM) is prominent in the scar and potently regulates cell behavior. However, comprehensive information about the ECM proteome is largely lacking, and region- as well as injury-specif...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-27 | PXD017478 | Pride
Central nervous system Macrophages Gliosis Brain injury Scarring Extracellular matrix 
ProteomicsComprehensive proteome of the adult neural stem cell niche identifies key regulators of adult neurogenesis
Neural stem cells (NSCs) generating new neurons are restricted to few niches in the adult mammalian brain, while the remainder rather promotes gliogenesis. Here we take advantage of the spatial separation of an NSC niche (the subependymal zone) and the region to where the newly generated neurons mig...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-27 | PXD016632 | Pride
Brain Stem cells Extracellular matrix Neurogenesis 
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