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TranscriptomicsSingle cell RNA-seq to investigate transcriptional profiles of thymic double negative T cells in WT, NPM-ALK(Tg/+) and NPM-ALK(Tg/+)Cdk6-/-Stat5b-/- mice
To examine transcriptional differences in thymic double negative (DN) T cells between wildtype (WT), NPM-ALK(Tg/+) and NPM-ALK(Tg/+)Cdk6-/-Stat5b-/- mice, single-cell RNA sequencing (scRNA-seq) was performed on fluorescence-activated cell sorted (FACS) DN T cells. The aim was to understand how genet...
ORGANISM(S): Mus musculus 
2026-07-24 | E-MTAB-15478 | biostudies-arrayexpress
TranscriptomicsGenomic_analysis_of_408_myeloproliferative neoplasm(MPN)_samples
Genomic DNA of granulocytes or mononuclear cell fractions of 408 myeloproliferative neoplasm (MPN) patients was analyzed using Affymetrix Genome-Wide Human SNP 6.0 arrays
ORGANISM(S): Homo sapiens 
2011-07-01 | E-MTAB-608 | biostudies-arrayexpress
ProteomicsPhosphochromatome profiling of C-terminally truncated CDK6
Pre/pro-B-cell lines were generated from bone marrow cells of Cdk6-/- mice by retroviral overexpression of the BCR-ABL (p185) fusion oncogene. These cell lines were transduced with constructs expressing HA-tagged versions of wildtype Cdk6 or of a C-terminally truncated variant of Cdk6 (HA-Cdk6-ΔC)....
ORGANISM(S): Mus musculus (Mouse) 
2024-12-19 | PXD059037 | Pride
Cycline dependent kinase 6 C-lobe 
ProteomicsInteractome of C-terminally truncated CDK6
Pre/pro-B-cell lines were generated from bone marrow cells of Cdk6-/- mice by retroviral overexpression of the BCR-ABL (p185) fusion oncogene. These cell lines were transduced with constructs expressing HA-tagged versions of wildtype Cdk6 or of a C-terminally truncated variant of Cdk6 (HA-Cdk6-ΔC)....
ORGANISM(S): Mus musculus (Mouse) 
2024-12-19 | PXD058474 | Pride
Cyclin-dependent kinase 6 C-terminus Ip mass spec 
TranscriptomicsSingle cell RNA Seq to study the effects of kinase-inactivated Cdk6 or a Cdk6 knock-out in the mouse LSK cell compartment
To understand kinase-dependent and kinase-independent functions of Cdk6 in the hematopoietic stem and progenitor compartment, mouse models carrying wild-type Cdk6 (Cdk6_WT), a homozygous knock-in of a kinase-inactivated variant of Cdk6 (Cdk6_K43M) or a homozygous Cdk6 knock-out (Cdk6_KO) were used. ...
ORGANISM(S): Mus musculus 
2024-05-22 | E-MTAB-13149 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA Seq to study the effects of Palbociclib in the mouse LSK cell compartment
To understand how Palbociclib (a CDK4/6 inhibitor) treatment changes the transcriptome of hematopoietic stem and progenitor cells, wildtype cells were isolated from mice and treated for 24h with either PBS (control) or Palbociclib. After 24h of culture, the cell suspensions were collected and sorted...
ORGANISM(S): Mus musculus 
2024-05-22 | E-MTAB-13268 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of murine megakaryocyte progenitors (MkPs) from Cdk6 knockout and Cdk6 wild-type CALR-mutant mice
This experiment was performed to elucidate the effects of CDK6 on CALR-mutant Myeloproliferative Neoplasms. VavCre CALRdel52 knockin mice were crossed with full-body Cdk6-/- mice to obtain Cdk6-/- CALRdel52 mice. Bone marrow from mice of the four genotypes Cdk6+/+ CALR+/+ (wild-type), Cdk6+/+ CALRde...
ORGANISM(S): Mus musculus 
2026-08-03 | E-MTAB-15404 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human and murine ALCL cell lines to compare interspecies similarity and genetic dependencies on CDK6 or STAT5B
To explore transcriptional similarities between human and murine Anaplastic Large Cell Lymphoma (ALCL) cell lines, RNA sequencing was performed across both species. The human cell lines included SU-DHL-1, DEL, SUP-M2, Karpas-299, SR-786, Mac1 and Mac2a. Additionally, murine cell lines derived from t...
ORGANISM(S): Mus musculus 
2026-07-24 | E-MTAB-15486 | biostudies-arrayexpress
GenomicsChIP-seq of STAT5B in human ALCL cell lines and CDK6 in a murine ALCL cell line
To investigate direct genomic targets of CDK6 and STAT5B in Anaplastic Large Cell Lymphoma (ALCL), ChIP-sequencing (ChIP-seq) was performed in both human and murine ALCL cell lines. We performed ChIP targeting STAT5B in five human ALCL cell lines (SU-DHL-1, DEL, SUP-M2, Karpas-299, SR-786) and ChIP ...
ORGANISM(S): Homo sapiens 
2026-07-24 | E-MTAB-15481 | biostudies-arrayexpress
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