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TranscriptomicsMicroarray correpsonding to the paper manuscript titled: Targeted expression profiling of single disseminated cancer cells isolated from bone marrow of prostate cancer patients
Bone is the most frequent site of metastasis in prostate cancer (PCa) and patients with bone metastases are deemed incurable. Targeting prostate cancer cells that disseminated to the bone marrow (BM) prior to surgery and before metastatic outgrowth may therefore prevent lethal metastasis. This promp...
ORGANISM(S): Homo sapiens 
2014-10-20 | E-GEOD-59631 | biostudies-arrayexpress
TranscriptomicsTranscriptome partitioning in mouse fertilization.
RNA transcripts are distributed non-uniformly in the oocytes of many animals, such that newly-divided embryo cells (blastomeres) inherit distinct transcriptomes following fertilization. In animals such as the frog, Xenopus laevis, programmed transcript regionalization directs early embryonic axis fo...
ORGANISM(S): Mus musculus 
2011-04-21 | E-GEOD-27396 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of early dendritic cell DC development in hematopoietic progenitor cell line FDCP-mix that is permissive for DC differentiation in the presence of GMCSF
To identify transcription factors that control dendritic cell development, we performed transcriptional profiling analyses of the murine hematopoietic progenitor cell line FDCP-mix that is permissive for DC differentiation in the presence of GMCSF.We reasoned that GM-CSF modulates a defined set of d...
ORGANISM(S): Mus musculus 
2004-08-18 | E-MEXP-151 | biostudies-arrayexpress
TranscriptomicsProfiling of single murine bronchioalveolar stem cells
Murine bronchioalveolar stem cells play a key role in pulmonary epithelial maintenance and repair but their molecular profile is poorly described so far. In this study, we used antibodies directed against Sca-1 and CD34, two markers originally ascribed to pulmonary cells harboring regenerative poten...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-52215 | biostudies-arrayexpress
TranscriptomicsMolecular profiling of single circulating tumor cells with diagnostic intention
About 230 clinical trials currently explore the role of circulating tumor cell (CTC) analysis for therapy decisions, but no assays enable comprehensive molecular characterization of CTCs with diagnostic precision. We therefore combined a workflow for CTC enrichment and isolation with 100% purity wit...
ORGANISM(S): Homo sapiens 
2014-11-05 | E-GEOD-58192 | biostudies-arrayexpress
TranscriptomicsReliable single cell array CGH for clinical samples
Establishment and subsequent validation of a aCGH protocol for WGA (whole genome amplification) products originating from single cell or low amount of starting material (i.e. microdissected FFPE tissue samples). The establishment of the protocol involved testing of three DNA labeling protocols. Two ...
ORGANISM(S): Homo sapiens 
2014-01-21 | E-GEOD-52366 | biostudies-arrayexpress
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