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MetabolomicsUrine Latin Square Spike-In for testing the NMR quantification tool, MetaboQuant
To test the quantification performance of MetaboQuant and other NMR quantification tools, a set of eight metabolites were added to replicates of a urine sample in varying concentrations. The metabolites were alanine, creatinine, histidine, betaine, acetate, phosphocreatine, β-hydroxybutyrate (BHBA) ...
2013-01-10 | MTBLS25 | MetaboLights
MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
ProteomicsSpatiotemporal proteomic profiling of Huntington's disease mice reveals widespread loss of protein function
Huntington's disease (HD) is characterized by the aggregation of polyglutamine-expanded huntingtin (HTT), proceeding from soluble oligomers to end-stage inclusions. The molecular mechanisms of how protein aggregation leads to neuronal dysfunction are not well understood. We employed mass spectrometr...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-24 | PXD004973 | Pride
Huntington's disease / inclusion bodies / neurodegeneration / quantitative proteomics 
ProteomicsThe UGT2B17 metabolic pathway as a key determinant of liver homeostasis: evidence from the hepatic proteome of individuals naturally deficient in UGT2B17
One of the most crucial pathways involved in the metabolism and detoxification of drugs and endobiotics is the glucuronidation process, primarily occurring in the liver. This pathway is catalyzed by glycosyltransferases comprising 22 enzymes such as UGT2B17, which is entirely absent in a large propo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000095873 | MassIVE
ProteomicsDynamic human liver proteome atlas reveals functional insights into disease pathways
Deeper understanding of liver pathophysiology would benefit from a comprehensive quantitative proteome resource at cell-type resolution. Here, we quantify more than 10,000 proteins and 150,000 sequence-unique peptides across total liver, the major liver cell types, time-course of primary cell cultur...
ORGANISM(S): Homo sapiens (Human) 
2022-05-08 | PXD027722 | Pride
Human Atlas Primary cell culture Liver Liver disease Cirrhosis Nash 
ProteomicsOntology-guided clustering enables proteomic analysis of rare pediatric disorders
The study of rare pediatric disorders is fundamentally limited by small patient numbers, making it challenging to draw meaningful conclusions about their molecular basis. To address this, we developed a framework that integrates clinical ontologies with proteomic profiling, enabling the systematic a...
ORGANISM(S): Homo sapiens (Human) 
2025-06-10 | PXD058960 | Pride
Pediatrics / plasma / proteomics / snomed ct / urine 
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