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MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
ModelsPetelenzKuehn_osmoadaptation_gpd1D
Petelenz-kurdzeil2013 - Osmo adaptation gpd1D This model is described in the article: Quantitative analysis of glycerol accumulation, glycolysis and growth under hyper osmotic stress. Petelenz-Kurdziel E, Kuehn C, Nordlander B, Klein D, Hong KK, Jacobson T, Dahl P, Schaber J...
2024-09-02 | BIOMD0000000610 | BioModels
ProteomicsMurine keratinocytes NFAT5 knockout secretome LC-MS/MS
The skin protects the human body against dehydration and harmful challenges. Keratinocytes (KCs) are the most frequent epidermal cells, and it is anticipated that KC-mediated transport of Na+ ions creates a physiological barrier of high osmolality against the external environment. We studied in KCs ...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-16 | PXD028675 | Pride
Mouse Keratinocyte Mus musculus Udmse Lfq Nfat5 Secretome Lc-ms/ms 
UnknownDepletion of STAT5 blocks TEL-SYK-induced APMF-type leukemia with myelofibrosis and myelodysplasia in mice.
Not available
S-EPMC4219468 | biostudies-literature
TranscriptomicsTranscriptome analysis of WEHI B lymphoma cells overexpressing individual NFATc1 proteins
In lymphocytes, NFATc1 is the most prominent NFAT transcription factor which play a crucial role in the fate and activity of peripheral T and B cells. NFATc1 is synthesized in two prominent isoforms, the inducible short isoform NFATc1/aA and the constitutively expressed long isoform NFATc1/C. Severa...
ORGANISM(S): Mus musculus 
2016-07-01 | E-MTAB-4665 | biostudies-arrayexpress
TranscriptomicsNFATc1 controls the survival, function and suppressive capacity of B lymphocytes upon B cell receptor stimulation
Triggering of B cell receptors (BCR) induces a massive synthesis of NFATc1 in splenic B cells. By inactivating the Nfatc1 gene and re-expressing NFATc1 we show that NFATc1 levels are critical for the survival of splenic B cells upon BCR stimulation. NFATc1 ablation led to decreased BCR-induced Ca++ ...
ORGANISM(S): Mus musculus 
2011-03-23 | E-GEOD-21063 | biostudies-arrayexpress
UnknownCarrageenan and insulin resistance in humans: a randomised double-blind cross-over trial.
Not available
S-EPMC11590543 | biostudies-literature
Genomicsena-DATASET-DEEP-08-06-2015-12:48:05:403-429 - samples
Human monocytes from a healthy male blood donor were obtained after written informed consent and anonymised. Library preparation was performed essentially as described in the “Whole‐genome Bisulfite Sequencing for Methylation Analysis (WGBS)” protocol as released by Illumina. The library was sequenc...
EGAD00001001390 | EGA
GenomicsEvolutionary origin and methylation status of human intronic CpG islands that are not present in mouse
Imprinting of the human RB1 gene is due to the presence of a differentially methylated CpG island (CGI) in intron 2, which is part of a retrogene derived from the PPP1R26 gene on chromosome 9. The murine Rb1 gene does not have this retrogene and is not imprinted. We have investigated whether the RB1...
EGAS00001000719 | EGA
GenomicsDEEP (Deutsches Epigenom Programm) DAC
Data Access Committee EGAC00001000179
EGAC00001000179 | EGA
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