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ProteomicsLysine methylation promotes NFAT5 activation upon EGFR activation and predicts response to temozolomide
Temozolomide (TMZ) therapy offers minimal clinical benefits in patients with glioblastoma multiforme (GBM) with high EGFR activity, underscoring the need for effective combination therapy. Here, we show that tonicity-responsive enhancer binding protein (NFAT5) lysine methylation, is a determinant of...
ORGANISM(S): Homo Sapiens 
2022-11-01 | PXD037869 |
ProteomicsMurine keratinocytes NFAT5 knockout secretome LC-MS/MS
The skin protects the human body against dehydration and harmful challenges. Keratinocytes (KCs) are the most frequent epidermal cells, and it is anticipated that KC-mediated transport of Na+ ions creates a physiological barrier of high osmolality against the external environment. We studied in KCs ...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-16 | PXD028675 | Pride
Mouse Keratinocyte Mus musculus Udmse Lfq Nfat5 Secretome Lc-ms/ms 
ProteomicsDirect ionic stress sensing and mitigation by the transcription factor NFAT5
Homeostatic control of intracellular ionic strength is essential for protein, organelle and genome function, yet mechanisms that sense and enable adaptation to ionic stress remain poorly understood in animals. We find that the transcription factor NFAT5 directly senses solution ionic strength using ...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-17 | PXD052591 | Pride
Hypertonic stress Proximity biotinylation Biomolecular condensates Ionic stress Intrinsically disordered protein Nfat5 Tonebp Phase separation 
TranscriptomicsNFAT5 is a critical regulator of rheumatoid inflammation
NFAT5 is an osmoprotective transcription factor whose DNA binding domain shares structural homology with NFkappaB and other member of NFAT family, but its role in chronic inflammatory diseases remains unclear. The mRNA profiling of synoviocytes and endothelial cells transfected with NFAT5-targeted s...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-22956 | biostudies-arrayexpress
ProteomicsEarly adipogenesis is repressed through the newly identified FHL2-NFAT5 signaling complex
The LIM-domain-only protein FHL2 is a modulator of signal transduction and has been shown to direct the differentiation of mesenchymal stem cells toward osteoblasts and myocytes phenotypes. We hypothesized that FHL2 may simultaneously interfere with the induction of the adipocyte lineage. Therefore,...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-13 | PXD033974 | Pride
Adipocyte Protein-protein interaction Fhl2 Nfat5 
GenomicsNFAT5 induction by the tumor microenvironment enforces CD8 T cell exhaustion [NFAT5 KO]
NFAT5 induction by the tumor microenvironment enforces CD8 T cell exhaustion [NFAT5 KO]
PRJNA862104 | ENA
TranscriptomicsMurine Spleen: Wild type vs Brx haploinsufficiency
Comaprison of the gene expression profiles of the spleen between wild type and Brx haploinsuffieint mice Nuclear factor of activated T-cells 5 (NFAT5) is a transcription factor that regulates hyperosmolarity-responsive genes and helps activated T lymphocytes adapt to and discharge their functions i...
ORGANISM(S): Mus musculus 
2009-02-09 | E-GEOD-10117 | biostudies-arrayexpress
GenomicsNFAT5 Controls the Integrity of Skin I
NFAT5 Controls the Integrity of Skin I
PRJNA763513 | ENA
GenomicsNFAT5 Controls the Integrity of Skin II
NFAT5 Controls the Integrity of Skin II
PRJNA763515 | ENA
TranscriptomicsGene expression from bone-marrow derived macrophages.
Gene expression from WT and NFAT5 KO primary macrophage cultures. Keywords: Bone-marrow derived macrophages. We analyzed 4 arrays from each condition: unstimulated WT BMDMs, LPS stimulated WT BMDMs, unstimulated KO BMDMs, LPS stimulated KO BMDMs.
ORGANISM(S): Mus musculus 
2012-01-20 | E-GEOD-26343 | biostudies-arrayexpress
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