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TranscriptomicsTranscription profiling of mouse embryonic fibroblasts from FHL2-/- and wild type animals
The LIM-only protein FHL2 acts as a transcriptional modulator that positively or negatively regulates multiple signaling pathways. We recently reported that FHL2 cooperates with CBP/p300 in the activation of ß-catenin/TCF target gene cyclin D1. In this paper, we demonstrate that FHL2 is associated ...
ORGANISM(S): Mus musculus 
2008-06-18 | E-GEOD-10902 | biostudies-arrayexpress
TranscriptomicsOverexpression of four and a half LIM domains protein 2 promotes epithelial-mesenchymal transition-like phenotype in fish pre-osteoblasts
Four and a half LIM domains protein 2 (FHL2) is a co-regulator of gene transcription relevant for many signalling pathways and physiological processes. In this work, the role of FHL2 in cell differentiation has been investigated during in vitro mineralization using a Sparus aurata pre-osteoblast cel...
ORGANISM(S): Sparus aurata 
2013-01-03 | E-GEOD-32501 | biostudies-arrayexpress
ProteomicsEarly adipogenesis is repressed through the newly identified FHL2-NFAT5 signaling complex
The LIM-domain-only protein FHL2 is a modulator of signal transduction and has been shown to direct the differentiation of mesenchymal stem cells toward osteoblasts and myocytes phenotypes. We hypothesized that FHL2 may simultaneously interfere with the induction of the adipocyte lineage. Therefore,...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-13 | PXD033974 | Pride
Adipocyte Protein-protein interaction Fhl2 Nfat5 
ProteomicsXL-MS analysis of recombinant full-length human FHL2
Four-and-a-half LIM domains protein 2 (FHL2) is a modular adaptor protein composed entirely of LIM domains that mediate protein–protein interactions linking the cytoskeleton to transcriptional regulation. In this study, full-length human FHL2 was recombinantly expressed in Escherichia coli and purif...
ORGANISM(S): Homo sapiens (Human) 
2026-09-01 | PXD078621 | Pride
Human Fhl2 Xl-ms Lim domain Zinc finger Bs3 
TranscriptomicsFunction of LIM-only protein FHL2 in vascular smooth muscle cells
The LIM-only protein FHL2 is expressed in SMCs and inhibits SMC-rich lesion formation. However, the underlying mechanism behind FHL2's action in SMCs has been only partially resolved. To further elucidate the role of FHL2 in SMCs we compared the transcriptome of cultured SMCs derived from wild-type ...
ORGANISM(S): Mus musculus 
2014-10-07 | E-GEOD-56860 | biostudies-arrayexpress
GenomicsFour-and-a-half LIM domain protein 2 (FHL2) deficiency protects mice from diet-induced obesity and high FHL2 expression correlates with obesity in man.
Four-and-a-half LIM domain protein 2 (FHL2) deficiency protects mice from diet-induced obesity and high FHL2 expression correlates with obesity in man.
PRJNA656490 | ENA
GenomicsEarly adipogenesis is regulated through the newly identified FHL2-NFAT5 signaling complex
Early adipogenesis is regulated through the newly identified FHL2-NFAT5 signaling complex
PRJNA827188 | ENA
TranscriptomicsDifferential expression between FHL2-/- and WT MEFs.
The LIM-only protein FHL2 acts as a transcriptional modulator that positively or negatively regulates multiple signaling pathways. We recently reported that FHL2 cooperates with CBP/p300 in the activation of ß-catenin/TCF target gene cyclin D1. In this paper, we demonstrate that FHL2 is associated w...
ORGANISM(S): Mus musculus 
2008-06-06 | GSE10902 | GEO
TranscriptomicsFour-and-a-half LIM domain protein 2 (FHL2) deficiency protects mice from diet-induced obesity and high FHL2 expression correlates with obesity in man.
Four-and-a-Half-LIM-domain-protein 2 (FHL2) modulates multiple signal transduction pathways but has not been implicated in obesity or energy metabolism. In man, FHL2 expression increases with age and high FHL2 expression is associated with increased body weight in human and mice, leading us to hypot...
ORGANISM(S): Mus musculus 
2021-06-14 | GSE156027 | GEO
TranscriptomicsGene expression analysis of FHL2-knockout mouse liver
FHL2 is known to be deregulated in liver cancer. In the present study, microarray gene expression profiling was performed to identify the genes regulated downstream of FHL2 In this dataset, we compared the RNA samples from livers of FHL2 knockout mice and those of wild-type (WT) mice.
ORGANISM(S): Mus musculus 
2012-01-01 | GSE26904 | GEO
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