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TranscriptomicsNFATc1 controls the survival, function and suppressive capacity of B lymphocytes upon B cell receptor stimulation
Triggering of B cell receptors (BCR) induces a massive synthesis of NFATc1 in splenic B cells. By inactivating the Nfatc1 gene and re-expressing NFATc1 we show that NFATc1 levels are critical for the survival of splenic B cells upon BCR stimulation. NFATc1 ablation led to decreased BCR-induced Ca++ ...
ORGANISM(S): Mus musculus 
2011-03-23 | E-GEOD-21063 | biostudies-arrayexpress
ProteomicsMurine keratinocytes NFAT5 knockout secretome LC-MS/MS
The skin protects the human body against dehydration and harmful challenges. Keratinocytes (KCs) are the most frequent epidermal cells, and it is anticipated that KC-mediated transport of Na+ ions creates a physiological barrier of high osmolality against the external environment. We studied in KCs ...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-16 | PXD028675 | Pride
Mouse Keratinocyte Mus musculus Udmse Lfq Nfat5 Secretome Lc-ms/ms 
TranscriptomicsTranscriptome analysis of WEHI B lymphoma cells overexpressing individual NFATc1 proteins
In lymphocytes, NFATc1 is the most prominent NFAT transcription factor which play a crucial role in the fate and activity of peripheral T and B cells. NFATc1 is synthesized in two prominent isoforms, the inducible short isoform NFATc1/aA and the constitutively expressed long isoform NFATc1/C. Severa...
ORGANISM(S): Mus musculus 
2016-07-01 | E-MTAB-4665 | biostudies-arrayexpress
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