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TranscriptomicsTranscription profiling of human embryonic kidney cells HEK293 overexpressing the transcription factors HNF4a2 or mutant forms HNF4a2 C106R and HNF4a2 R154X to identify HNF4a regulated genes in kidney cells being several of these genes deregulated in renal cell carcinoma
Analysis of gene expression in human embryonic kidney cells HEK293 overexpressing the transcription factors HNF4a2 or mutant forms HNF4a2 C106R and HNF4a2 R154X, which were introduced by FRT/FLP recombination. The analysis was performed 24 hours following 1sg/ml tetracycline treatment to induce the ...
ORGANISM(S): Homo sapiens 
2007-10-30 | E-GEOD-2700 | biostudies-arrayexpress
TranscriptomicsIn Vitro Transcriptome Analysis of Porcine Plexus Epithelial Cells in Response to Streptococcus suis: Functions of the Choroid Plexus in Antimicrobial Defense
We used microarrays to detail the global gene expression changes following apical infection of porcine choroid plexus epithelial cells (PCPEC) with Streptococcus suis (S. suis) We compared PCPEC either un-treated or infected with wild-type S. suis strain 10 or the acapsular strain 10cpsDEF, respecti...
ORGANISM(S): Sus scrofa 
2011-08-14 | E-GEOD-23751 | biostudies-arrayexpress
TranscriptomicsMassive decrease of maternal polyA mRNA upon post-ovulatory aging in Xenopus tropicalis
We used microarrays to detail the global gene expression changes following aging of oocytes We compared fresh oocytes with post-ovulatory aged oocytes by microarray analysis
ORGANISM(S): Xenopus (Silurana) tropicalis 
2011-03-29 | E-GEOD-21109 | biostudies-arrayexpress
TranscriptomicsMalignant Fibrous Histiocytoma - Pleomorphic Sarcoma, NOS -Gene expression, Histology and clinical course -A pilot study
This study was performed to identify gene expression differences in not otherwise specified soft tissue sarcomas (NOS, malignant fibrous histiocytomas) and correlate them to histological findings and the clinical course. RNA was isolated and differential gene expression was analysed by the microarra...
ORGANISM(S): Homo sapiens 
2011-01-03 | E-GEOD-14325 | biostudies-arrayexpress
TranscriptomicsEffect of FTO overexpression and knockdown on transcriptome of HEK293 cells
To gain insight into FTO function, we knocked down and overexpressed FTO in HEK293 cells.Genetrail analyses of expression profiles pointed to the RNA splicing and processing machinery. Intriguingly, using immunocytochemistry and confocal laser scanning microscopy, we observed strong enrichment of FT...
ORGANISM(S): Homo sapiens 
2012-11-13 | E-GEOD-33870 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse primitive and maturing hematopoietic stem cells
Gene expression studies from hematopoietic stem cell (HSC) populations purified to variable degrees have defined a set of stemness genes. The present study describes the construction and comparative molecular analysis of l-phage cDNA libraries from highly purified primitive HSCs (PHSCs) which retain...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4391 | biostudies-arrayexpress
TranscriptomicsAltering gene expression by aminocoumarin (novobiocin) treatment: Role of DNA supercoiling in Staphylococcus aureus
For Staphylococcus aureus it was shown previously that aminocoumarinecoumarin antibiotics such as novobiocin lead to immediate down-regulation of recA expression and thereby inhibition of the SOS response, the mutation frequency and the recombination capacity. Aminocoumarinecoumarin function by inh...
ORGANISM(S): Staphylococcus aureus 
2014-09-08 | E-GEOD-50157 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse mammary C57MG cells transfected with Wnt-1 or empt vector to identify targets of Wnt-1
RNA from murine mammary C57MG cells transfected with an empty control vector (PLNCx) or an expression vector encoding Wnt-1 was isolated and analyzed on Affymetrix MG-U74Av2 arrays. Sample preparation was done as recommended by the manufacturer. Images were analyzed using Affymetrix Microarray Suite...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-1899 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human prolymphocytic leukemina T-cells and normal T-cells
T-cell prolymphocytic leukemina (T-PLL) is an agressive lymphoma derived from mature T-cells, which is in most cases characterized by the presence of an inv(14)(q11q32) and a characteristic pattern of secondary chromosomal abberations. We used microarrays to compare the transcriptomes of eight immun...
ORGANISM(S): Homo sapiens 
2008-12-10 | E-GEOD-5788 | biostudies-arrayexpress
TranscriptomicsEverolimus protects podocytes via stabilizing TUBB2B and DCDC2 expression
Glomerular podocytes are highly differentiated cells that are key components of the kidney filtration units. The podocyte cytoskeleton builds the basis for the dynamic podocyte cytoarchitecture and plays a central role for proper podocyte function. Recent studies implicate that immunosuppressive age...
ORGANISM(S): Homo sapiens 
2015-09-09 | E-GEOD-66107 | biostudies-arrayexpress
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