Sort   by:  
 Page size 
TranscriptomicsThe codon 72 polymorphism of p53 regulates interactions with NF-κB and transactivation of genes involoved in immunity and inflamation
A common polymorphism at codon 72 in the p53 tumor suppressor gene encodes either proline(P72) or arginine(R72). These two variants might possess altered biological function which influences p53’s transcriptional, senescence and apoptotic functions. We found that P72 has increased apoptosis when com...
ORGANISM(S): Mus musculus 
2011-01-25 | E-GEOD-26851 | biostudies-arrayexpress
TranscriptomicsPeriostin, a cell adhesion molecule, facilitates invasion in the tumor microenvironment and annotates a novel tumor invasive signature in esophageal cancer
Human squamous cell cancers are the most common epithelially derived malignancies. One example is esophageal squamous cell carcinoma (ESCC), which is associated with a high mortality rate that is related to a propensity for invasion and metastasis. We report that periostin, a highly expressed cell a...
ORGANISM(S): Homo sapiens 
2010-07-08 | E-GEOD-21293 | biostudies-arrayexpress
MetabolomicsAberrant accumulation of cyclin D1 rewires glutamine metabolism via loss of IDH3 generating metabolic vulnerability in ESCC and HNSCC

Excessive cyclin D1 accumulation is a frequent oncogenic event in head and neck squamous cell carcinoma (HNSCC) and esophageal squamous cell carcinoma (ESCC). Although classically associated with enhanced proliferation and genomic instability, we reveal that cyclin D1 dysregulation induces unexpe...

2026-08-24 | MTBLS13687 | MetaboLights
UnknownLIN28B induces a differentiation program through CDX2 in colon cancer.
Not available
S-EPMC8262288 | biostudies-literature
UnknownIMP1 3' UTR shortening enhances metastatic burden in colorectal cancer.
Not available
S-EPMC6556707 | biostudies-literature
UnknownFC-IBC-02: A New in vitro-in vivo Model of Triple Negative Inflammatory Breast Cancer
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-40464 | biostudies-other
TranscriptomicsAnalysis of FoxA2 occupancy in mouse liver with endoderm ChIP-chip array
Understanding how silent genes can be competent for activation provides insight into development as well as cellular reprogramming and pathogenesis. We performed genomic location analysis of the pioneer transcription factor FoxA in the adult liver and found that about one-third of the FoxA bound si...
ORGANISM(S): Mus musculus 
2011-07-18 | E-GEOD-23551 | biostudies-arrayexpress
UnknownThe LIN28B-IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine.
Not available
S-EPMC6075153 | biostudies-literature
TranscriptomicsFC-IBC-02: A New in vitro-in vivo Model of Triple Negative Inflammatory Breast Cancer
Inflammatory breast cancer (IBC) is the most aggressive type of advanced breast cancer and is associated with a poor prognosis. We have developed a new model of IBC derivated from the pleural effusion of a 49-year-old woman with metastatic secondary IBC. FC-IBC02 tumor cells were isolated from the p...
ORGANISM(S): Homo sapiens 
2012-09-20 | E-GEOD-40464 | biostudies-arrayexpress
UnknownRab11-FIP1 mediates Epithelial-Mesenchymal Transition and invasion in esophageal cancer
Not available
S-SCDT-EMBOR-2019-48351V1P | biostudies-other
Sort   by:  
 Page size