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ProteomicsLiver phosphoproteomics in response to AgRP activated neurons in the presence/absence of NPY
Autophagy represents a key regulator of aging and metabolism upon cell autonomous sensing of energy deprivation. We find that fasting in mice activates autophagy in liver paralleled by activation of hypothalamic AgRP neurons. Optogenetic and chemogenetic activation of AgRP neurons induces autophagy,...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-18 | PXD029247 | Pride
Phosphoproteomics Dia Liver Lc-ms/ms 
ProteomicsIFITM3-mediated regulation of cell membrane dynamics is essential for malignant B-cell transformation
B cell receptor (BCR) signaling and oncogenic tyrosine kinases that mimic BCR-signaling in B-lineage leukemia and lymphoma depend on assembly of membrane proximal signaling complexes. Signalosomes in normal BCR- and oncogene (e.g. BCR-ABL1, RAS-pathway lesions) signal transduction are recruited to p...
ORGANISM(S): Mus musculus (Mouse) 
2020-12-18 | PXD014691 | Pride
Leukemia Bcr signaling Cell surface Lipid rafts 
ProteomicsIFITM3 BioID Interactomes in B-ALL and MCL
To determine the roles of membrane associated IFITM3 in BCR-signalling in B-cell malignancies we expressed N-terminal BirA-IFITM3-Y20E fusion or BirA-EV control in patient derived B-ALL cells (PDX2) and Jeko1 Mantle cell lymphoma (MCL) cells. Additionally to examine the role of PIP3 binding residues...
ORGANISM(S): Homo sapiens (Human) 
2020-12-18 | PXD020697 | Pride
Human b-all mcl b-cells 
ProteomicsIFITM3 amino acid mutants phosphoproteomics
To investigate the role of IFITM3 in B-ALL, patient derived xenograft cells PDX2 were transduced with either a the constitutively membrane associated IFITM3-Y20E mutant or EV control. Additional mutation of PIP3 binding sites within the conserved internal loop region - K83/K104 or R85/R87/K88 - were...
ORGANISM(S): Homo sapiens (Human) 
2020-12-18 | PXD020696 | Pride
Pdx b-all b-cell 
UnknownIFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells.
Not available
S-EPMC8087162 | biostudies-literature
UnknownEffect of Celecoxib vs Placebo as Adjuvant Therapy on Disease-Free Survival Among Patients With Breast Cancer: The REACT Randomized Clinical Trial.
Not available
S-EPMC8283666 | biostudies-literature
UnknownGlobal diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 <i>Salmonella</i> Typhi genomes.
Not available
S-EPMC10506625 | biostudies-literature
UnknownColorectal-cancer incidence and mortality with screening flexible sigmoidoscopy.
Not available
S-EPMC3641846 | biostudies-literature
UnknownMortality results from a randomized prostate-cancer screening trial.
Not available
S-EPMC2944770 | biostudies-literature
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