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GenomicsChIP-Seq of Klf4 in NMuMG normal murine mammary gland epithelial cells.
Chromatin immunoprecipitation of Klf4 in NMuMG cells identifies gene promoter sequences that are directly bound by Klf4. Chromatin immunoprecipitation using a Klf4-specific antibody in NMuMG cells followed by next generation sequencing (ChIP-Seq).
ORGANISM(S): Mus musculus 
2013-08-01 | E-GEOD-49445 | biostudies-arrayexpress
ProteomicsKLF4-PFKFB3-driven glycolysis is essential for phenotypic switching of vascular smooth muscle cells
Vascular smooth muscle cells (VSMCs) within atherosclerotic lesions undergo a phenotypic switching in a KLF4-dependent manner. Glycolysis plays important roles in transdifferentiation of somatic cells, however, it is unclear whether and how KLF4 mediates the link between glycolytic switch and VSMCs ...
ORGANISM(S): Homo Sapiens 
2022-11-09 | PXD038057 |
TranscriptomicsRNAi knock down of Klf4 in mouse embryonic stem cells
To characterize Klf4 downstream genes, we performed microarray analyses of the ES cells knocked down by siRNA of Klf4 gene.
ORGANISM(S): Mus musculus 
2006-11-08 | E-MNIA-92 | biostudies-arrayexpress
ProteomicsKLF4 binding is involved in the organization and regulation of 3D enhancer networks during acquisition and maintenance of pluripotency.
Cell fate transitions are accompanied by global transcriptional, epigenetic and topological changes driven by transcription factors (TFs), as is strikingly exemplified by reprogramming somatic cells to pluripotent stem cells (PSCs) via expression of OCT4, KLF4, SOX2 and cMY...
ORGANISM(S): Mus musculus (Mouse) 
2019-09-03 | PXD014631 | Pride
Pluripotency Ipscs Stem cells Rime Chromatin 
TranscriptomicsExpression data of cHL cell lines after KLF4 activation
Characteristic extinguishing of B-cell phenotype in cHL is believed to be a result of transcription factor network deregulation due to the overexpression of repressor proteins ID2 and ABF-1. KLF4 is a versatile transcription factor, participating in regulation of differentiation processes in various...
ORGANISM(S): Homo sapiens 
2010-10-22 | E-GEOD-21296 | biostudies-arrayexpress
TranscriptomicsIdentifying targets of Klf2, Klf4, Klf5 and p53 in mouse embryonic stem cells
This SuperSeries is composed of the following subset Series: GSE9774: Klf2, Klf4, Klf5 and p53 in mouse embryonic stem cells GSE9775: To identify the target genes of Klf2, Klf4 and Klf5 in mouse embryonic stem cells. Keywords: SuperSeries Refer to individual Series
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-9535 | biostudies-arrayexpress
TranscriptomicsKlf4 gene disruption is linked to enhanced cellular proliferation and tumor formation
Kruppel-like factor 4 (KLF4) is involved in diverse biological processes such as cell cycle control, differentiation, transcriptional regulation, DNA repair and apoptosis. Furthermore, KLF4 is a tumor suppressor and play a role in regulating genomic stability. In order to investigate the changes in ...
ORGANISM(S): Mus musculus 
2010-11-25 | E-GEOD-21768 | biostudies-arrayexpress
TranscriptomicsFunGenES: INS-3-1: Expression profiling of CGR8 cells after downregulation of Klf4 or Klf5.
This experiment is part of the FunGenES project (FunGenES - Functional Genomics in Embryonic Stem Cells partially funded by the 6th Framework Programme of the European Union, http://www.fungenes.org). The experiment was conducted at Inserm U846, Bron, France. Aim: Kru_ppel-like factors (Klf) 4 and 5...
ORGANISM(S): Mus musculus 
2014-04-28 | E-MTAB-1838 | biostudies-arrayexpress
TranscriptomicsKlf4 is a transcriptional regulator of genes critical for EMT, including Jnk1 (Mapk8).
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-08-01 | E-GEOD-49451 | biostudies-arrayexpress
TranscriptomicsFunGenES: INS-4-1: Expression profiling of CGR8 cells after upregulation of Klf4 or Klf5 expression.
This experiment is a follow-up experiment of the FunGenES project (FunGenES - Functional Genomics in Embryonic Stem Cells partially funded by the 6th Framework Programme of the European Union, http://www.fungenes.org). The experiment was conducted at Inserm U846, Bron, France. Aim: Kru_ppel-like fac...
ORGANISM(S): Mus musculus 
2014-04-28 | E-MTAB-1839 | biostudies-arrayexpress
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