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Transcriptomics19 K14Cre; p53F/F mouse mammary tumor analysis
Tumor formation is in part driven by copy number alterations (CNAs), which can be measured using array Comparative Genomic Hybridization (aCGH). Identifying regions of DNA that are gained or lost in a significant fraction of tumor samples can facilitate identification of genes possibly related to th...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-7794 | biostudies-arrayexpress
TranscriptomicsRNA-seq of 675 commonly used human cancer cell lines
Tumor-derived cell lines have served as vital models to advance our understanding of oncogene function and therapeutic response1. Although substantial effort has been directed to defining the genomic constitution of cancer cell line panels24, the transcriptome which represents the active program of...
ORGANISM(S): Homo sapiens 
2014-11-25 | E-MTAB-2706 | biostudies-arrayexpress
TranscriptomicsLack of genetic heterogeneity at high-resolution aCGH between primary breast cancers and their paired lymph node metastases
Lymph-node (LN) metastases predict for high recurrence rates in breast cancer patients. Eradication of micro-metastatic tumor cells is the primary goal of adjuvant systemic treatment. Decisions regarding systemic treatment depend largely on primary tumor characteristics rather than on characteristic...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-38888 | biostudies-arrayexpress
TranscriptomicsYap1/Birc, c-Met and N-ras DNA amplifications are mutually exclusive in mouse mammary tumors.
Tumors acquire somatic DNA copy number aberrations, leading to activation of oncogenes and inactivation of tumor suppressors. Many studies have focused on the analysis of single copy number aberrations and associated driver genes, but few studies have performed combinatorial analyses. We propose a g...
ORGANISM(S): Mus musculus 
2011-12-01 | E-GEOD-28432 | biostudies-arrayexpress
TranscriptomicsaCGH analysis of Palb2GT/+;p53-/- and Palb2+/+;p53-/- lymphomas
Palb2 interacts with BRCA1 and BRCA2 in supercomplexes involved in DNA repair via homologous recombination. Heterozygous germline mutations in PALB2 confer a moderate risk of breast cancer while biallelic PALB2 mutations are linked to a severe form of Fanconi anaemia characterized by early childhood...
ORGANISM(S): Mus musculus 
2011-01-21 | E-GEOD-26723 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization by array of mouse Brca1 and Brca2 mammary tumors
Comparison of mammary tumors from 35 Brca1F/F;p53F/F, 62 Brca2F/F;p53F/F and 33 p53F/F mice. For each mouse, tumor DNA was hybridized with its spleen DNA as a reference.
ORGANISM(S): Mus musculus 
2010-12-15 | E-NCMF-34 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization by array of mouse Brca1 and Brca2 mammary tumors
Comparison of mammary tumors from 35 Brca1F/F;p53F/F, 62 Brca2F/F;p53F/F and 33 p53F/F mice. For each mouse, tumor DNA was hybridized with its spleen DNA as a reference.
ORGANISM(S): Mus musculus 
2010-12-15 | E-NCMF-35 | biostudies-arrayexpress
GenomicsHigh-throughput semi-quantitative analysis of insertional mutations in heterogeneous tumors
Exploiting the full potential of insertional mutagenesis screens with retroviruses and transposons requires methods for distinguishing clonal from subclonal insertion events within heterogeneous tumor cell populations. Current protocols, based on ligation mediated PCR, depend on endonuclease based f...
ORGANISM(S): Mus musculus 
2011-08-11 | E-GEOD-22657 | biostudies-arrayexpress
Genomicsena-DATASET-GENENTECH-24-01-2014-01:33:01:945-58 - samples
This dataset contains RNA sequencing data for 675 cancer cell lines. RNA libraries were made with the TruSeq RNA Sample Preparation kit (Illumina) according to the manufacturer protocol. The libraries were sequenced on an Illumnia HiSeq 2000
EGAD00001000725 | EGA
TranscriptomicsA novel preclinical mouse model of spontaneous breast cancer metastasis
Metastatic disease remains one of the most urgent clinical challenges accounting for over 90% of cancer-related deaths. Yet, the identification of novel therapeutic targets to fight or prevent metastatic disease has been hampered by the limited availability of clinically relevant mouse models of met...
ORGANISM(S): Mus musculus 
2011-12-23 | E-GEOD-34666 | biostudies-arrayexpress
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