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ProteomicsChronic stress targets mitochondrial respiratory efficiency in the skeletal muscle of C57BL/6 mice. PMID: 36988756
Episodes of chronic stress can result in psychic disorders like post-traumatic stress disorder, but also promote the development of metabolic syndrome and type 2 diabetes. We hypothesize that muscle, as main regulator of whole-body energy expenditure, is a central target of acute and adaptive molecu...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-08 | PXD042472 | Pride
Chronic variable stress Mouse Liver Isolated mitochondria Mitochondrial function 
ProteomicsRhein, a novel Histone Deacetylase (HDAC) inhibitor with antifibrotic potency in human myocardial fibrosis
Although fibrosis depicts a reparative mechanism, maladaptation of the heart due to excessive production of extracellular matrix accelerates cardiac dysfunction. The anthraquinone Rhein was examined for its anti-fibrotic potency to mitigate cardiac fibroblast-to-myofibroblast transition (FMT). Prima...
ORGANISM(S): Homo sapiens (Human) 
2020-03-23 | PXD016731 | Pride
Dia Spectronaut Hypoxia Fibrosis Lumos Cardiac remodeling Secretome Hdac inhibition 
ProteomicsLong-term adjustment of hepatic lipid metabolism after chronic stress and the role of FGF21
Chronic stress leads post-traumatic stress disorder (PTSD) and to metabolic complications, including fatty liver. It is feasible, that stress immediately initiates molecular mechanisms to alter energy metabolism and glucose homeostasis which interfere with hepatic lipid accumulation after stress rec...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-10 | PXD025268 | Pride
Secreted proteins Fatty liver Mouse hepatocytes Long-term effects of chronic stress 
ProteomicsAdaption of oxidative phosphorylation machinery compensates hepatic lipotoxicity in early stages of MAFLD, isolated mitochondria PMID:3543314
Mitochondrial function is an important control variable in the progression of metabolic dysfunction associated fatty liver disease (MAFLD). We hypothesize that organization and function of mitochondrial electron transport chain (ETC) in this pathologic condition is a consequence of shifted substrate...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-02 | PXD032211 | Pride
Mouse Mafld  isolated mitochondria Mitochondrial function 
ProteomicsAdaption of oxidative phosphorylation machinery compensates hepatic lipotoxicity in early stages of MAFLD; PMID:35743314
Mitochondrial function is an important control variable in the progression of metabolic dysfunction associated fatty liver disease (MAFLD). We hypothesize that organization and function of mitochondrial electron transport chain (ETC) in this pathologic condition is a consequence of shifted substrate...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-02 | PXD032214 | Pride
Mouse Mafld  isolated hepatocytes Mitochondrial function 
ProteomicsChronic stress targets mitochondrial respiratory efficiency in the skeletal muscle of C57BL/6 mice.
Episodes of chronic stress can result in psychic disorders like post-traumatic stress disorder, but also promote the development of metabolic syndrome and type 2 diabetes. We hypothesize that muscle, as main regulator of whole-body energy expenditure, is a central target of acute and adaptive molecu...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-31 | PXD035798 | Pride
Chronic variable stress Mouse Gastrocnemius muscle Isolated mitochondria Mitochondrial function 
TranscriptomicsA mutation in the c-Fos gene associated with congenital generalized lipodystrophy
Lipodystrophies resemble syndromes of disturbed adipocyte biology or development and severe congenital forms (CGL) lack adipose tissue. The ubiquitous immediate-early gene c-fos is one essential transcription factor to initiate adipocyte differentiation. In a CGL patient we identified a single homoz...
ORGANISM(S): Homo sapiens 
2013-08-07 | E-GEOD-39825 | biostudies-arrayexpress
TranscriptomicsAnalyses of a deactivation genetic variation in Ha-Ras proto oncogene identified in a patient wit premature aging and insulin resistance
Inherited genetic variants of insulin receptor induced cellular signaling have long been suspected to contribute to the development of type-2- diabetes mellitus. In this report we discuss a heterozygous mutation in the first coding exon of the proto-oncogene Ha-Ras (Ha-RasA11P) that we have identifi...
ORGANISM(S): Homo sapiens 
2013-08-07 | E-GEOD-49566 | biostudies-arrayexpress
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