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GenomicsBulk Liver in MAFLD/MASH
Bulk Liver in MAFLD/MASH
PRJNA1109378 | ENA
ProteomicsTransketolase promotes MAFLD by limiting inosine-induced mitochondrial activity (Proteomics)
Metabolic dysfunction-associated fatty liver disease (MAFLD) has a global prevalence of about 25% and no approved therapy. Using metabolomic and proteomic analyses, we identified high expression of hepatic transketolase (TKT), a metabolic enzyme of the pentose phosphate pathway, in human and mouse M...
ORGANISM(S): Homo Sapiens 
2024-02-26 | PXD050130 |
ProteomicsAdaption of oxidative phosphorylation machinery compensates hepatic lipotoxicity in early stages of MAFLD; PMID:35743314
Mitochondrial function is an important control variable in the progression of metabolic dysfunction associated fatty liver disease (MAFLD). We hypothesize that organization and function of mitochondrial electron transport chain (ETC) in this pathologic condition is a consequence of shifted substrate...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-02 | PXD032214 | Pride
Mouse Mafld  isolated hepatocytes Mitochondrial function 
ProteomicsAdaption of oxidative phosphorylation machinery compensates hepatic lipotoxicity in early stages of MAFLD, isolated mitochondria PMID:3543314
Mitochondrial function is an important control variable in the progression of metabolic dysfunction associated fatty liver disease (MAFLD). We hypothesize that organization and function of mitochondrial electron transport chain (ETC) in this pathologic condition is a consequence of shifted substrate...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-02 | PXD032211 | Pride
Mouse Mafld  isolated mitochondria Mitochondrial function 
GenomicsBulk White Blood Cells in MAFLD/MASH
Bulk White Blood Cells in MAFLD/MASH
PRJNA1109377 | ENA
ProteomicsQuantitative proteomics analysis based on data-independent acquisition reveals the effect of Shenling Baizhu powder (SLP) on protein expression in MAFLD rat liver tissue
Metabolic fatty liver disease (MAFLD) has become the most common chronic liver disease worldwide, with steatosis as the underlying pathology. At the same time, MAFLD is also a high-risk factor for the development of metabolic diseases. Shenling Baizhu powder (SLP) is a traditional Chinese herbal for...
ORGANISM(S): Rattus Norvegicus 
2023-05-07 | PXD042049 |
TranscriptomicsBulk Liver in MAFLD/MASH
Background & Aims: Metabolic dysfunction associated steatotic liver disease (MAFLD) progresses to steatohepatitis (MASH) and is a major cause of liver cirrhosis. In the early disease stage, liver inflammation is absent. However, the early involvement of the peripheral immune cell compartments in dis...
ORGANISM(S): Homo sapiens 
2025-04-30 | GSE267031 | GEO
GenomicsDifferences in gene expression of liver tissues between MAFLD patients and controls.
Differences in gene expression of liver tissues between MAFLD patients and controls.
PRJNA759700 | ENA
GenomicsHuman fecal samples of MAFLD patients and Healthy people
Human fecal samples of MAFLD patients and Healthy people Raw sequence reads
PRJNA930148 | ENA
TranscriptomicsBulk White Blood Cells in MAFLD/MASH
Background & Aims: Metabolic dysfunction associated steatotic liver disease (MAFLD) progresses to steatohepatitis (MASH) and is a major cause of liver cirrhosis. In the early disease stage, liver inflammation is absent. However, the early involvement of the peripheral immune cell compartments in dis...
ORGANISM(S): Homo sapiens 
2025-04-30 | GSE267032 | GEO
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