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UnknownThe Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse infection model.
Not available
S-EPMC2168236 | biostudies-literature
TranscriptomicsLong-term adaptation to hypoxic conditions - Febit transcriptome analysis
Aspergillus fumigatus is an opportunistic, airborne pathogen causing invasive aspergillosis in immunocompromised patients. During the infection process A. fumigatus is challenged by hypoxic microenvironments occurring in inflammatory, necrotic tissue. To gain further insights into the adaptation mec...
ORGANISM(S): Aspergillus fumigatus 
2014-07-01 | E-MTAB-2699 | biostudies-arrayexpress
TranscriptomicsAntigen specific human conventional T cells (CD154+) or regulatory T cells (CD137+) directed agains A. fumigatus or Birch pollen lysate isolated from Birch pollen allergic patients or healthy controls.
Foxp3+ regulatory T cells (Treg) play a central role for tolerance against self and innocuous environmental antigens. However, the role of antigen-specificity for Treg-mediated tolerance is only incompletely understood. Here we show by direct ex vivo characterization of human CD4+ T cells, that the ...
ORGANISM(S): Homo sapiens 
2016-10-25 | E-GEOD-77018 | biostudies-arrayexpress
UnknownInduction of Mitochondrial Reactive Oxygen Species Production by Itraconazole, Terbinafine, and Amphotericin B as a Mode of Action against Aspergillus fumigatus.
Not available
S-EPMC5655112 | biostudies-literature
TranscriptomicsNext Generation Sequencing identifies O2-responsive genes in the human pathogenic fungus Aspergillus fumigatus
Low oxygen conditions are not only common to natural environments but also occur during tissue invasive growth in the human host. Only few cellular factors have been identified up to now that allow the fungus to efficiently adapt its energy metabolism to the lack of O2. In the present study, we cult...
ORGANISM(S): Aspergillus fumigatus 
2014-07-25 | E-GEOD-55943 | biostudies-arrayexpress
ProteomicsIdentification of proteomic markers in head and neck cancer using MALDI-MS Imaging, LC-MS/MS and IHC
Purpose The heterogeneity of squamous cell carcinoma tissue complicates diagnosis and an individualized therapy to a great extent. Therefore it is of utmost importance to spatially characterize this tissue heterogeneity and to identify appropriate biomarkers. Matrix assisted laser desorption/ionizat...
ORGANISM(S): Homo sapiens (Human) 
2018-11-14 | PXD009144 | Pride
Cancer Maldi-ms imaging Immunohistochemistry Biomarker Lc-ms/ms 
UnknownIntegrative analysis of the heat shock response in Aspergillus fumigatus.
Not available
S-EPMC2820008 | biostudies-literature
ProteomicsCreA phosphorylation sites are important for the regulation of carbon catabolite repression in filamentous fungi
Saprobic microorganisms, such as filamentous fungi of the genus Aspergillus, are of particular interest for biotechnological applications due to their natural capacity to secrete plant cell wall-degrading enzymes that are known as carbohydrate-active enzymes (CAZy). The presence of easily metaboliza...
ORGANISM(S): Emericella nidulans (Aspergillus nidulans) 
2021-02-18 | PXD018967 | Pride
Lc-ms Aspergillus nidulans Crea Carbon catabolite repression Phosphoproteomics 
ProteomicsIdentification of proteins interacting with cytoplasmic high-mobility group box 1 (HMGB1) during the hepatocellular response to ischemia reperfusion injury
Ischemia/reperfusion injury (IRI) occurs in liver transplantations and major resections and can lead to liver dysfunction. HMGB1 locates in nucleus of normal hepatocytes, but translocates to cytoplasm and the extracellular space during IRI. Although the functions of nuclear and extracellular HMGB1 a...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-03-10 | PXD003538 | Pride
2d-ge Hmgb1 Lc-ms Ischemia 
UnknownAnaerobic mineralization of quaternary carbon atoms: isolation of denitrifying bacteria on dimethylmalonate.
Not available
S-EPMC91498 | biostudies-literature
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