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ProteomicsPhospho-proteome of vascular smooth muscle cells derived from abdominal aortic aneurysm patients
For this experiment, primary smooth muscle cells (SMC) were isolated from abdominal aortic aneurysm (AAA) patients. Control SMC (c-SMC) were isolated from non-dilated human aortas. SMC contraction from AAA-patients and controls was measured. SMC contraction from AAA patients shows a broad range, wit...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD054353 | Pride
Abdominal aortic aneurysm  contractile function  proteomics  vascular biology  vascular smooth muscle cells 
ProteomicsProteomic profiling of a large cohort of HCM patients: genotype-specific protein changes
Hypertrophic cardiomyopathy (HCM) is characterized by asymmetric left ventricular (LV) hypertrophy and diastolic dysfunction, which leads to LV outflow tract obstruction (LVOTO) in the majority of cases. Mutations in genes encoding sarcomeric proteins cause HCM and are identified in more than half o...
ORGANISM(S): Homo sapiens (Human) 
2021-01-14 | PXD012467 | Pride
Myectomy Hypertrophic cardiomyopathy Label-free Hcm Spectral counting 
OtherFeasibility of label-free phosphoproteomics and application to base-line signaling of colorectal cancer cell lines.
Data from ProteomeXchange, PXD ID: PXD001550. File: QE2_130117_OPL1013_TiOx_CRC_DLD1_3_130125023714.mzml. Published as part of J Proteomics. 2015 Apr 1. pii: S1874-3919(15)00103-7 . From the Abstract: {{i}} Robust phosphopeptide enrichment methods with minimal fractionation are required to profile ...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320014765 | GPMDB
Resource Reanalysis 
ProteomicsEvaluation of phospho-tyrosine antibodies for label-free phosphoproteomics
In the past decade multiple tyrosine kinase inhibitors (TKIs) have been implemented in standard treatment regimens for patients with cancer. Unfortunately the majority of patients develops resistance to these drugs. Reliable tools for analysis of pharmacodynamic effects and drug resistance mechanism...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-21 | MSV000080270 | MassIVE
UnknownSex-Related Differences in Protein Expression in Sarcomere Mutation-Positive Hypertrophic Cardiomyopathy.
Not available
S-EPMC7956946 | biostudies-literature
UnknownPhosphotyrosine-based Phosphoproteomics for Target Identification and Drug Response Prediction in AML Cell Lines.
Not available
S-EPMC7196578 | biostudies-literature
ProteomicsThe phosphoproteomic landscape of two FLT3+ Acute Myeloid Leukemia (AML) patient samples-LYSATES.
Acute myeloid leukemia (AML) is a clonal hematopoietic malignancy, characterized by expansion of immature leukemic blasts in the bone marrow. In AML, specific tyrosine kinases have been implicated in leukemogenesis, and are associated with poor treatment outcome. However, targeted therapy using kina...
ORGANISM(S): Homo sapiens (Human) 
2020-03-02 | PXD015662 | Pride
Human Single-shot Tyrosine kinase Flt3 Label-free Phosphoproteomics Acute myeloid leukemia Aml 
ProteomicsThe phosphoproteomic landscape of two FLT3+ Acute Myeloid Leukemia (AML) patient samples.
Acute myeloid leukemia (AML) is a clonal hematopoietic malignancy, characterized by expansion of immature leukemic blasts in the bone marrow. In AML, specific tyrosine kinases have been implicated in leukemogenesis, and are associated with poor treatment outcome. However, targeted therapy using kina...
ORGANISM(S): Homo sapiens (Human) 
2020-03-02 | PXD015639 | Pride
Human Single-shot Tyrosine kinase Flt3 Label-free Phosphoproteomics Acute myeloid leukemia Aml 
UnknownPhosphoproteomic Characterization of Primary AML Samples and Relevance for Response Toward FLT3-inhibitors.
Not available
S-EPMC8202661 | biostudies-literature
UnknownWestern diet triggers cardiac dysfunction in heterozygous Mybpc3-targeted knock-in mice: A two-hit model of hypertrophic cardiomyopathy.
Not available
S-EPMC11708371 | biostudies-literature
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