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GenomicsGenome-wide analyses reveal the extent of opportunistic STAT5 binding that does not yield transcriptional activation of neighboring genes.
Signal Transducers and Activators of Transcription (STAT) 5A/B regulate cytokine-inducible genes upon binding to GAS motifs. It is not known what percentage of genes with GAS motifs bind to and are regulated by STAT5. Moreover, it is not clear whether genome-wide STAT5 binding is modulated by its co...
ORGANISM(S): Mus musculus 
2012-01-12 | E-GEOD-34986 | biostudies-arrayexpress
UnknownER-to-lysosome Ca2+ refilling followed by K+ efflux-coupled store-operated Ca2+ entry in inflammasome activation and metabolic inflammation.
Not available
S-EPMC11219040 | biostudies-literature
UnknownHistone Lys demethylase KDM3C demonstrates anti-inflammatory effects by suppressing NF-κB signaling and osteoclastogenesis.
Not available
S-EPMC6704463 | biostudies-literature
UnknownDegradation of selenoprotein S and selenoprotein K through PPARγ-mediated ubiquitination is required for adipocyte differentiation.
Not available
S-EPMC6748118 | biostudies-literature
ProteomicsAXIN1 boosts antiviral response through IRF3 stabilization and induced phase separation
Axis inhibition protein 1 (AXIN), a scaffold protein interacting with various critical molecules, plays a vital role in determining cell fate. However, its impact on the antiviral innate immune response remains largely unknown. Here, we identify AXIN acts as an effective regulator of antiviral in...
ORGANISM(S): Homo sapiens (Human) 
2024-10-31 | PXD055972 | Pride
Human Irf3 Axin1 
ProteomicsAXIN1 boosts antiviral response through IRF3 stabilization and induced phase separation
Axis inhibition protein 1 (AXIN), a scaffold protein interacting with various critical molecules, plays a vital role in determining cell fate. However, its impact on the antiviral innate immune response remains largely unknown. Here, we identify AXIN acts as an effective regulator of antiviral in...
ORGANISM(S): Homo sapiens (Human) 
2024-11-01 | PXD055574 | Pride
Human Irf3 Axin1 
GenomicsGenome-wide maps of GATA factor occupancy in K562 cells
GATA factors interact with simple DNA motifs (WGATAR) to regulate critical processes, including hematopoiesis, but very few WGATAR motifs are occupied in genomes. Given the rudimentary knowledge of mechanisms underlying this restriction, and how GATA factors establish genetic networks, we used ChIP-...
ORGANISM(S): Homo sapiens 
2009-11-25 | E-GEOD-18868 | biostudies-arrayexpress
UnknownKorean Multicenter Registry of ELUVIA Stent for Femoropopliteal Artery Disease: K-ELUVIA Registry.
Not available
S-EPMC11361770 | biostudies-literature
UnknownStructural and biological insights into Klebsiella pneumoniae surface polysaccharide degradation by a bacteriophage K1 lyase: implications for clinical use.
Not available
S-EPMC8822698 | biostudies-literature
TranscriptomicsNuclear orphan receptor TAK1/TR4-deficient mice are protected against obesity-linked inflammation, hepatic steatosis, and insulin resistance
The nuclear receptor TAK1/TR4/NR2C2 is expressed in several tissues that are important in the control of energy homeostasis. TAK1-deficient (TAK1-/-) mice are resistant to the development of age- and high fat diet (HFD)-induced metabolic syndrome. Biochemical analysis showed significantly lower hepa...
ORGANISM(S): Mus musculus 
2010-09-30 | E-GEOD-21903 | biostudies-arrayexpress
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