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TranscriptomicsPF4-Cre mediated deletion of SRF in murine megakaryocytes.
Srf is a MADS-box transcription factor that is critical for muscle differentiation. Its function in hematopoiesis has not yet been revealed. Mkl1, a cofactor of Srf, is part of the t(1;22) translocation in acute megakaryoblastic leukemia, and plays a critical role in megakaryopoiesis. In order to te...
ORGANISM(S): Mus musculus 
2010-07-13 | E-GEOD-21859 | biostudies-arrayexpress
TranscriptomicsComparison of granulosa cells from WT and Inha KO mice following gonadotropin stimulation
Inhibin α knockout (Inha-/-) female mice develop sex cord-stromal ovarian cancer with complete penetrance and previous studies demonstrate that the pituitary gonadotropins [follicle stimulating hormone (FSH) and luteinizing hormone (LH)] are influential modifiers of granulosa cell tumor development ...
ORGANISM(S): Mus musculus 
2011-02-01 | E-GEOD-20466 | biostudies-arrayexpress
TranscriptomicsInducible expression of PrPC in mouse skeletal muscles results in myopathy characterized by changes in gene expression
Over-expression of wild type PrP in skeletal muscles is sufficient to cause a primary myopathy with no signs of peripheral neuropathy, possibly due to accumulation of a cytotoxic truncated form of PrP and/or PrP aggregation. In this study we used DNA microarrays to identify 1499 transcripts that ar...
ORGANISM(S): Mus musculus 
2008-08-27 | E-GEOD-12576 | biostudies-arrayexpress
UnknownContribution of surface β-glucan polysaccharide to physicochemical and immunomodulatory properties of Propionibacterium freudenreichii.
Not available
S-EPMC3298172 | biostudies-literature
TranscriptomicsmRNA Expression Comparison Between Igfbp7-null and wild type mice at Lactation Day 3
Insulin like growth factor binding protein 7, Igfbp7, is a secreted protein that in addition to modulating insulin and insulin-like growth factor signaling, it acts as a tumor suppressor gene in breast and other cancers. To elucidate the role of Igfbp7 in regulating the proliferation and differentia...
ORGANISM(S): Mus musculus 
2014-09-02 | E-GEOD-45118 | biostudies-arrayexpress
TranscriptomicsVL30 retro-transposons are TRIM24-repressed enhancers that generate non-coding RNA to regulate gene expression in mouse hepatocytes.
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-39853 | biostudies-arrayexpress
TranscriptomicsA mex3 homolog is required for differentiation during planarian stem cell lineage development
Neoblasts are adult stem cells (ASCs) in planarians which sustain cell replacement during homeostasis and regeneration of any missing tissue. While numerous studies have examined genes underlying neoblast pluripotency, molecular pathways driving the postmitotic fate remain poorly defined. Here we...
ORGANISM(S): Schmidtea mediterranea 
2015-06-15 | E-GEOD-68581 | biostudies-arrayexpress
TranscriptomicsGene expression data from Wild Type and Nlrp10 deficient dendritic cells treated with or without LPS
Nlrp10-deficient mice have a profound defect in helper T cell-driven immune responses. T cell priming is impaired due to a defect in the emigration of a dendritic cells from inflamed tissue and antigen transport to draining lymph nodes. DC chemotaxis to CCR7-dependent and independent ligands is inta...
ORGANISM(S): Mus musculus 
2012-02-23 | E-GEOD-36009 | biostudies-arrayexpress
UnknownSimvastatin in Critically Ill Patients with Covid-19.
Not available
S-EPMC10755839 | biostudies-literature
UnknownEnhancing cognitive performance prediction by white matter hyperintensity connectivity assessment.
Not available
S-EPMC11629703 | biostudies-literature
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