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TranscriptomicsRNAPII CTD dataset
The C-terminal domain (CTD) of RNA polymerase II (RNAPII) is composed of heptapeptide repeats, which play a key regulatory role in gene expression. Using genetic interaction and mRNA expression analysis we found that truncating the CTD resulted in distinct changes to cellular function. Truncating th...
ORGANISM(S): Saccharomyces cerevisiae 
2013-09-13 | E-GEOD-43120 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiling of somatic tissues from normal and trisomic fetuses
The DNA methylation profiles in normal and abnormal fetal development were investigated using Illumina GoldenGate Methylation Cancer Panel I. DNA methylation status of 1505 CpG dinucleotides located in the regulatory regions of 807 genes was measured in 5 somatic tissues (brain, kidney, lung, muscle...
ORGANISM(S): Homo sapiens 
2011-05-06 | E-GEOD-25283 | biostudies-arrayexpress
TranscriptomicsThe Biological Residue of Low Early-Life Social Class
Research shows that children who are reared in households with low socioeconomic status are more vulnerable to heart disease, respiratory infection, and some cancers when they reach adulthood. This study conducted transcriptional profiling of PBMC in healthy adults who were low vs. high in early-lif...
ORGANISM(S): Homo sapiens 
2009-03-10 | E-GEOD-15180 | biostudies-arrayexpress
TranscriptomicsDot1 and Histone H3K79 Methylation in Natural Heterochromatic and HML/HMR Silencing
Dot1 is a methyl transferase that has been shown through a reporter gene to be involved in position effect variegation of gene expression in heterochrmatic regions such as telomeres and the mating type loci in yeast. This study examines the effect of mutation of DOT1 and two other proteins involved ...
ORGANISM(S): Saccharomyces cerevisiae 
2011-02-12 | E-GEOD-27234 | biostudies-arrayexpress
TranscriptomicsDistinct DNA methylation patterns of cognitive impairment and Trisomy 21 in Down Syndrome
The presence of an extra whole or part of chromosome 21 in people with Down syndrome (DS) is associated with multiple neurological changes, including pathological aging that often meets the criteria for Alzheimer’s Disease (AD). While the mechanism underlying these changes is unknown, it has been hy...
ORGANISM(S): Homo sapiens 
2014-01-02 | E-GEOD-50586 | biostudies-arrayexpress
TranscriptomicsDECREASED FIBRONECTIN PRODUCTION SIGNIFICANTLY CONTRIBUTES TO DYSREGULATED REPAIR OF ASTHMATIC EPITHELIUM
Rationale: Damage to airway epithelium is followed by deposition of extracellular matrix (ECM) and migration of adjacent epithelial cells. We have shown that epithelial cells from asthmatic children fail to heal a wound in vitro. Objectives: To determine whether dysregulated ECM production by the ep...
ORGANISM(S): Homo sapiens 
2010-04-12 | E-GEOD-18965 | biostudies-arrayexpress
UnknownAirway Aging and Methylation Disruptions in HIV-associated Chronic Obstructive Pulmonary Disease.
Not available
S-EPMC9887412 | biostudies-literature
TranscriptomicsGene deletion expression profiles of yeast chromatin modifiers
Packaging of DNA into chromatin has a profound impact on gene expression. To understand how changes in chromatin influence transcription, we analyzed 165 mutants of chromatin machinery components in Saccharomyces cerevisiae. mRNA expression patterns change in 80% of mutants, always with specific eff...
ORGANISM(S): Saccharomyces cerevisiae 
2011-05-23 | E-GEOD-25909 | biostudies-arrayexpress
ProteomicsSystems biology of blood and tissue for comprehensive analysis of immune response to hepatitis B vaccine in adults
Protein concentrations of both lysed WBC and plasma samples were measured by the PierceTM Bradford Assay and normalized to contain 10 μg per sample before proceeding with sample digestion using the procedure as previously described44. Peptides were desalted using STop-And-Go Extraction tips (STAGE t...
ORGANISM(S): Homo sapiens (Human) 
2020-12-01 | PXD020474 | Pride
Tissue Blood Systems biology Hepatitis b vaccone 
UnknownMRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription-replication conflicts.
Not available
S-EPMC6753070 | biostudies-literature
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