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TranscriptomicsTranscription profiling of mouse inflammatory response to titanium dioxide particles exposure is enhanced during pregnancy
Rationale: Maternal immune responses can promote allergy development in offspring. Pilot data show that neonates of mother mice exposed during pregnancy to air pollution particles have increased allergic susceptibility. Objective: We investigated whether inflammatory response to titanium dioxide (Ti...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7475 | biostudies-arrayexpress
TranscriptomicsEffect of estradiol on murine alveolar macrophages and RAW264.7 cells in vitro
Mouse BAL alveolar macrophages from pregnant E14 and control dams are compared to RAW cells cultured with estradiol to determine shared gene expression change patterns induced by pregnancy and estrogen BAL cells from intact pregnant and control mice were directly processed for RNA extraction. RAW ce...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-52649 | biostudies-arrayexpress
TranscriptomicsEffect of miR-182 on macrophage infection with Francisella tularensis
miR-182 over-expression enhances macrophage resistance to intracellular pathogens. This transcriptional profiling experiment was conducted to identify the basis for protection. Primary human alveolar macrophage-like monocyte derived macrophages were transfected with miR-182 mimic or control RNA, the...
ORGANISM(S): Homo sapiens 
2018-01-05 | E-MTAB-4551 | biostudies-arrayexpress
TranscriptomicsEpigenomic analysis of neonatal dendritic cells in mice with increased allergic susceptibility
RATIONALE: In a mouse model of maternal transmission of asthma risk (J. Immunol 170:1683, 2003), baby mice of asthmatic (As), but not normal (Nrm), mothers show increased susceptibility to allergy. We previously showed that adoptive transfer to normal baby mice of dendritic cells (DCs) harvested fro...
ORGANISM(S): Mus musculus 
2010-06-24 | E-GEOD-13380 | biostudies-arrayexpress
TranscriptomicsEffect of allergen sensitization on gene expression in dendritic cells from neonates of asthmatic vs control mothers
This study aims to demonstrate the link between epigenome-wide methylation aberrations at birth and genomic transcriptional changes upon allergen sensitization that occur in the neonatal dendritic cells (DC) due to maternal asthma. In an in vivo model reproducing human epidemiology findings, materna...
ORGANISM(S): Mus musculus 
2013-06-01 | E-GEOD-44678 | biostudies-arrayexpress
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