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ProteomicsEpigenetic silencing of tight junction protein CLDN10B in renal cancer including post-transplantation RCC and its endogenous reactivation by CRISPR results in cell growth suppression.
Background The kidney's tubular system, composed of nephrons and collecting ducts, relies on cellular planar polarity and tight junctions to maintain structure and function. Disruptions in this polarity contribute to diseases like cystic kidney disease and cancer. Tight junctions, such as those form...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-01 | MSV000095998 | MassIVE
ProteomicsMulti-omics profiling of Müller cells in diabetic retinopathy identifies the glucocorticoid receptor as a master regulator of gliotic response
Diabetic retinopathy (DR), the leading cause of blindness in working-age adults, is thought to be primarily a microvascular complication of diabetes. As a central element of the retinal neurovascular unit, Müller cells, the major macroglia of the retina, are important for maintaining a healthy and f...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-23 | PXD045085 | Pride
Diabetic retinopathy Proteomic analysis Expression profiling Müller glia Mrna 
ProteomicsMouse and rat liver and liver cell line LC-MS/MS
This study sought to interrogate the effects of lipids and lipid metabolites on the hepatic proteome. Protein expression and tyrosine phosphorylation in high-fat diet (HFD) mouse livers vs. livers of normal chow fed (NC) mice were investigated using multiplexed quantitative LC-MS/MS (TMT labeling). ...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2019-07-08 | PXD011458 | Pride
Mouse Rat Free fatty acids Liver Phosphotyrosine Lc-ms/ms Diabetes 
ProteomicsMouse liver expression additional replicates
This study sought to interrogate the effects of lipids and lipid metabolites on the hepatic proteome. Protein expression in high-fat diet (HFD) mouse livers vs. livers of normal chow fed (NC) mice were investigated using multiplexed quantitative LC-MS/MS (TMT labeling). This experiment contains addi...
ORGANISM(S): Mus musculus (Mouse) 
2019-07-08 | PXD013815 | Pride
Mouse Liver Expression High-fat diet Lc-ms/ms 
TranscriptomicsIGF1-receptor signalling attenuates the age-related decline of diastolic cardiac function
Insulin-like growth factor (IGF1R) signalling has been implicated to play an important role in regulation of cardiac growth, hypertrophy and contractile function, and has been linked to the development of age related congestive heart failure. Here we address the question to what extent cardiomyocyte...
ORGANISM(S): Mus musculus 
2012-07-31 | E-GEOD-32936 | biostudies-arrayexpress
UnknownMutation analysis in individual circulating tumor cells depicts intratumor heterogeneity in melanoma
Not available
S-SCDT-10_1038-S44321-024-00082-6 | biostudies-other
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