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UnknownPervasive correlations between causal disease effects of proximal SNPs vary with functional annotations and implicate stabilizing selection.
Not available
S-EPMC10723494 | biostudies-literature
ProteomicsChemical phosphoproteomic approaches reveal substrate specificity of protein phosphatases-1 and -2
The phosphatases PP1 and PP2A are responsible for the majority of dephosphorylation reactions on phosphoserine (pS) and –threonine (pT), and are involved in basically all cellular processes and many related diseases. They are thought to have no appreciable intrinsic substrate specificity, but to gai...
ORGANISM(S): Homo sapiens (Human) 
2020-07-14 | PXD012026 | Pride
Co-immunoprecipitation Phosphatase substrates Quantitative phosphoproteomics 
GenomicsWhole genome sequencing of spontaneous resistant mutants of Mycobacterium tuberculosis H37Rv selectec in the presence of BVL3572S and amino acids
M. tuberculosis H37Rv cultures were exposed to BVL3572S in the absence or presence of L-histidine or L-alanine for at least 4 weeks. Individual colonies were picked and their genomic DNA extracted, indexed, and sequenced.
ORGANISM(S): Mycobacterium tuberculosis 
2026-06-03 | E-MTAB-17255 | biostudies-arrayexpress
TranscriptomicsInduced Pluripotent Mesenchymal Stromal Cell Clones Retain Donor-Derived Differences in DNA Methylation Profiles
Reprogramming of somatic cells into induced pluripotent stem cells (iPSC) is an epigenetic phenomenon. It has been suggested that iPSC retain some tissue-specific memory whereas little is known about inter-individual epigenetic variation of iPSC clones. In this study we have reprogrammed mesenchymal...
ORGANISM(S): Homo sapiens 
2013-01-09 | E-GEOD-34688 | biostudies-arrayexpress
ProteomicsPharmacoproteomic characterisation of human colon and rectal cancer - CRC65 Full Proteomes
Most molecular cancer therapies act on protein targets but data on the proteome status of patients and cellular models are only beginning to emerge. Here, we profiled the proteomes of 65 colorectal cancer (CRC) cell lines to a depth of >10,000 proteins using mass spectrometry. Integration with prote...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-23 | MSV000081738 | MassIVE
ProteomicsPharmacoproteomic characterisation of human colon and rectal cancer - CPTAC Full Proteomes
Most molecular cancer therapies act on protein targets but data on the proteome status of patients and cellular models are only beginning to emerge. Here, we profiled the proteomes of 65 colorectal cancer (CRC) cell lines to a depth of >10,000 proteins using mass spectrometry. Integration with prote...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-23 | MSV000081739 | MassIVE
ProteomicsPharmacoproteomic characterisation of human colon and rectal cancer - CRC65 Kinobeads
Most molecular cancer therapies act on protein targets but data on the proteome status of patients and cellular models are only beginning to emerge. Here, we profiled the proteomes of 65 colorectal cancer (CRC) cell lines to a depth of >10,000 proteins using mass spectrometry. Integration with prote...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-23 | MSV000081735 | MassIVE
ProteomicsCritical Assessment of Metaproteome Investigation (CAMPI): a Multi-Lab Comparison of Established Workflows
Metaproteomics, the study of the collective proteome within a microbial ecosystem, has substantially grown over the past few years. This growth comes from the increased awareness that it can powerfully supplement metagenomics and metatranscriptomics analyses. Although metaproteomics is more challeng...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) Homo Sapiens (ncbitaxon:9606) 
2022-06-08 | MSV000089620 | MassIVE
TranscriptomicsRNA-seq and genome-wide CRISPRi and Tn-seq analyses of BVL3572S-treated Mycobacterium tuberculosis H37Rv
(i) RNA-seq of M. tuberculosis H37Rv cultures grown in the presence of BVL3572S for 6 h compared to untreated controls. (ii) Genome-wide M. tuberculosis H37Rv CRISPRi libraries were grown in the presence of ATc for 5 days prior to drug exposure. Cultures were treated with sub-MIC BVL3572S concentra...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2026-04-20 | E-MTAB-16773 | biostudies-arrayexpress
ProteomicsTarget Landscape of Clinical Kinase Inhibitors
Here, we provide a comprehensive overview of the selectivity profiles of 242 kinase inhibitors currently in clinical trials. We screened available inhibitors against human protein kinases by using the Kinobead technology resulting in a drug matrix identifying the druggable kinome and related protein...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-01-12 | MSV000081932 | MassIVE
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