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TranscriptomicsExpression data of HUVEC cells after TNF-alpha treatment
Tumor necrosis factor a (TNF-aplha) is a potent cytokine that orchestrates the inflammatory response by sequentially activating the expression of many genes in cultured human umbilical vein cells (HUVECs). We apply samples collected every 7.5 min to arrays and monitor the growth of several long tran...
ORGANISM(S): Homo sapiens 
2007-09-19 | E-GEOD-9036 | biostudies-arrayexpress
TranscriptomicsGlobal expression analysis of HNF4alpha and HNFgamma-mediated transcriptional control
Hepatocyte nuclear factor-4α (HNF4α, NR2A1) is a nuclear receptor which has a critical role in hepatocyte differentiation and the maintenance of homeostasis in the adult liver. However, a detailed understanding of native HNF4α in the steady state remains to be elucidated. Here we report the native H...
ORGANISM(S): Homo sapiens 
2010-12-22 | E-GEOD-18973 | biostudies-arrayexpress
TranscriptomicsIL-4 mediated gene expression profiles in vascular endothelial cells
Endothelial cell activation and dysfunction underlie many vascular disorders, including atherosclerosis and inflammation. Here, we show that interleukin (IL)-4 markedly induced vascular cell adhesion molecule (VCAM)-1, both in cultured endothelial cells and in the intact endothelium in mice. Combine...
ORGANISM(S): Homo sapiens 
2011-05-01 | E-GEOD-28117 | biostudies-arrayexpress
TranscriptomicsHIF1 is a master regulator of the adaptive gene expression to hypoxia.
Total 23 samples were derived from [1] HUVEC treated in the absence (0h) or presence of hypoxia (1, 2, 4, 8, 12, and 24 hrs) to determine hypoxia-regulated gene in endothelial cells, [2] control siRNA or HIF1? siRNA transfected HUVEC cells treated in the absence or presence of hypoxia, [3] control s...
ORGANISM(S): Homo sapiens 
2012-06-06 | E-GEOD-35932 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression analysis of gastric cancer by oligonucleotide microarrays
To gain molecular understanding of carcinogenesis, progression, and diversity of gastric cancer, 22 primary human advanced gastric cancer tissues and 8 noncancerous gastric tissues were analyzed by high-density oligonucleotide microarray in this study. Based on expression analysis of approximately 6...
ORGANISM(S): Homo sapiens 
2005-05-22 | E-GEOD-2685 | biostudies-arrayexpress
GenomicsGenome-wide maps of H3K27ac, PPARβ/δ and Pol II localization in HUVECs
H3K27Ac is one of the expressed enhancer markers, PPARβ/δ is a transcription factor and Pol II (RNA polymerase II) is an enzyme which catalyzes the transcription of DNA to synthesize precursors of mRNA and most snRNA and microRNA. These genomic localization in endothelial cells is unknown in endothe...
ORGANISM(S): Homo sapiens 
2014-03-06 | E-GEOD-50144 | biostudies-arrayexpress
GenomicsGenome-wide binding sites of Hypoxia inducible factor 1 (HIF1) and histone modifications
We report the high-throughput profilings of HIF1 and histone modifications in human umbilical vein endothelial cells (HUVEC). By obtaining over two billion bases of sequence from chromatin immunoprecipitated DNA, we generated genome-wide chromatin-state maps of HUVEC under normoxia and hypoxia. We f...
ORGANISM(S): Homo sapiens 
2012-07-12 | E-GEOD-39089 | biostudies-arrayexpress
GenomicsGenome-wide maps of H3K27ac localization in HUVECs
H3K27Ac is one of the expressed enhancer markers in endothelial cells, but its genomic localization is unknown. This time, we established a new antibody for H3K27ac, and performed ChIP-seq to identify H3K27ac binding site in whole genome manner under hypoxia. We used chromatin immunoprecipitation w...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-38555 | biostudies-arrayexpress
GenomicsGenome-wide maps of RNA Polymerase II and p65 localization in HUVECs stimulated with TNF alpha
TNF alpha is one of the inflammatory mediator and induce genes mainly by transcriptional factor, p65, in endothelial cells. This time, we performed a time course study to detect the change of localization of p65 and Pol II. To identify p65 and Pol II binding sites, we used chromatin immunoprecipit...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-34500 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of tolerizing murine cardiac allograft to understand the precise mechanisms of immunological tolerance.
C57/BL6 to C57/BL6; Balb/c to C57/BL6; Balb/c to C57/BL6 with anti CD80/86 mAb; Identificaton of gene expression profile in tolerizing murine cardiac allograft by co-stimulatory blockade. The induction of specific tolerance would be the ultimate achievement in transplant immunology, but the precise ...
ORGANISM(S): Mus musculus 
2007-12-15 | E-GEOD-582 | biostudies-arrayexpress
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