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ProteomicsScandiumIII
Recently, it has been reported that some metal complexes can act as artificial proteases. In particular, the Lewis acid scandium(III) triflate has been shown to catalyze the cleavage of peptide bonds N- and C-terminal to serine and threonine residues. Therefore, we investigated if this compound can ...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Equus caballus (Horse) 
2020-05-26 | PXD014918 | Pride
Endoproteinase Protein cleavage Mass spectrometry Scandium(iii) triflate Lewis acid 
ProteomicsIdentification of alternative splice variants using unique isoform-specific tryptic peptide sequences for database searches
Alternative splicing is a mechanism in eukaryotes by which different forms of messenger RNAs (mRNAs) are generated from the same gene. Identification of alternative splice variants requires the identification of peptides specific for alternative splice forms. For this purpose, we generated a human d...
ORGANISM(S): Homo sapiens (Human) 
2017-05-19 | PXD006026 | Pride
Protein species Proteomics Alternative splicing Mass spectrometry Phosphorylation Proteoform Isoforms 
ProteomicsHalf decimal place rule
Many MS2 spectra in bottom-up proteomics experiments remain unassigned. To improve proteome coverage, we applied the half decimal place rule (HDPR) to remove non-peptidic molecules. The HDPR considers the ratio of the first digit after the decimal point to the full molecular mass and results in a re...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080727 | MassIVE
UnknownThe <i>FANCM</i>:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer.
Not available
S-EPMC6825205 | biostudies-literature
UnknownMicroRNA related polymorphisms and breast cancer risk.
Not available
S-EPMC4229095 | biostudies-literature
UnknownGenome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
Not available
S-EPMC4549775 | biostudies-literature
UnknownIdentification of six new susceptibility loci for invasive epithelial ovarian cancer.
Not available
S-EPMC4445140 | biostudies-literature
UnknownRivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial.
Not available
S-EPMC6662613 | biostudies-literature
UnknownA second update on mapping the human genetic architecture of COVID-19.
Not available
S-EPMC10482689 | biostudies-literature
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