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ProteomicsTargeted Degradation of CDK9 Potently Disrupts the MYC Transcriptional Network
Cyclin-dependent kinase 9 (CDK9) coordinates signaling events that regulate RNA polymerase II (Pol II) pause-release states. It is an important co-factor for transcription factors, such as MYC, that drive aberrant cell proliferation when their expression is deregulated. CDK9 modulation offers an app...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD052300 | Pride
Cdk9 Myc Transcription Protacs Ribosome biogenesis 
UnknownEngineering and characterization of fluorogenic glycine riboswitches.
Not available
S-EPMC4937332 | biostudies-literature
TranscriptomicsGene expression profiling of articular cartilage reveals functional pathways and networks of candidate genes for osteochondrosis in pigs
Osteochondrosis disorder is characterized by a failure of endochondral ossification of the articular-epiphyseal cartilage and the physeal growth cartilage. The number and identity of relevant genes are unknown. Simultaneously, 24,123 probe-sets were screened, of which 12,292 had present in at least ...
ORGANISM(S): Sus scrofa 
2013-10-21 | E-GEOD-44991 | biostudies-arrayexpress
UnknownTransformer-based tool recommendation system in Galaxy.
Not available
S-EPMC10680333 | biostudies-literature
UnknownSearch for potential vaccine candidate open reading frames in the Bacillus anthracis virulence plasmid pXO1: in silico and in vitro screening.
Not available
S-EPMC133087 | biostudies-literature
UnknownVirtual healthcare solutions for cardiac rehabilitation: a literature review.
Not available
S-EPMC10039430 | biostudies-literature
UnknownTime-dependent investigation of a mechanochemical synthesis of bismuth telluride-based materials and their structural and thermoelectric properties.
Not available
S-EPMC8965406 | biostudies-literature
ProteomicsOrgan protection by caloric restriction depends on activation of the de novo NAD+ synthesis pathway
Therapeutic strategies to treat acute kidney injury (AKI) are lacking. Preconditioning by hypoxia (HP) and caloric restriction (CR) is highly protective in rodent AKI models. The underlying molecular mechanisms are unknown. A comparative transcriptome analysis after HP and CR identified Kynureninase...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-13 | PXD038328 | Pride
Kynu Hypoxia Caloric restriction Acute kidney injury Kynureninase Nad+ 
UnknownPersonalized Interactive Music Systems for Physical Activity and Exercise: Exploratory Systematic Review and Meta-Analysis.
Not available
S-EPMC12422526 | biostudies-literature
UnknownSelection against tandem splice sites affecting structured protein regions.
Not available
S-EPMC2279118 | biostudies-literature
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