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TranscriptomicsExpression data from IgE+ and IgG1+ B lymphocytes in mice infected with Nippostrongylus brasiliensis
The mechanisms involved in the maintenance of memory IgE responses are poorly understood, and the role played by germinal center (GC) IgE cells in these memory responses is particularly unclear. IgE B-cell differentiation is characterized by a transient GC phase, a bias towards the plasma cell (PC) ...
ORGANISM(S): Mus musculus 
2013-10-31 | E-GEOD-49033 | biostudies-arrayexpress
MetabolomicsPRDM15 is a master regulator of metabolism essential to sustain B-cell lymphomagenesis
PRDM family members are sequence-specific transcriptional regulators involved in cell identity and fate determination and are often dysregulated in cancer. The PRDM15 gene is of particular interest, given its relatively low expression in adult tissues and its overexpression in follicular lymphomas (...
2025-06-16 | MTBLS1639 | MetaboLights
TranscriptomicsThe role of the protein kinase-A pathway in the response to alkaline pH stress in yeast
Exposure of Saccharomyces cerevisiae to alkaline pH represents a stress condition that generates a compensatory reaction. Here we examine a possible role of the protein kinase-A (PKA) pathway in this response. The phenotypic analysis reveals that mutations that activate the PKA pathway (ira1 ira2, b...
ORGANISM(S): Saccharomyces cerevisiae 
2011-07-15 | E-GEOD-27925 | biostudies-arrayexpress
TranscriptomicsRegulation of the core pre-mRNA splicing machinery by MYC and PRMT5 is essential to sustain lymphomagenesis [B-cells]
Over-expressed MYC binds to virtually all active promoters within a cell, although with different binding affinities, and modulates gene expression, both positively and negatively. Here, we show that during lymphomagenesis in Eµ-myc transgenic mice, MYC directly up-regulates the transcription of the...
ORGANISM(S): Mus musculus 
2015-05-19 | E-GEOD-60188 | biostudies-arrayexpress
GenomicsA CpG mutational hotspot in a ONECUT (HNF6) binding site accounts for the prevalent variant of Hemophilia B Leyden
Hemophilia B, or the 'Royal Disease', arises from mutations in the Coagulation Factor IX (F9) gene. Mutations within the F9 promoter are associated with a remarkable form of the disease, termed Hemophilia B Leyden, in which symptoms ameliorate after puberty. Mutations at the -5/-6 site account for t...
ORGANISM(S): Mus musculus 
2013-03-06 | E-MTAB-890 | biostudies-arrayexpress
TranscriptomicsComparative ChIP-chip analysis of general transcription factor TFIIB and negative cofactor NC2 in human B cells
A comparative ChIP-chip analysis of TFIIB and NC2 in human B cells reveals that basal core promoter architectures control the equilibrium between NC2 and preinitiation complexes. We conducted a comparative ChIP-chip and gene expression analysis of TFIIB in human B cells and analyze associated core p...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-19562 | biostudies-arrayexpress
GenomicsPAX5 overexpression is not enough to reestablish the mature B-cell phenotype in classical Hodgkin lymphoma (ChIP-Seq)
In lymphomas derived from mature B cells the expression of the transcription factor PAX5 is maintained whereas classical Hodgkin lymphoma displays significantly reduced PAX5 expression despite its derivation from mature B cells. To elucidate the functional role of PAX5 in classical Hodgkin lymphoma,...
ORGANISM(S): Homo sapiens 
2013-07-30 | E-GEOD-44551 | biostudies-arrayexpress
TranscriptomicsRegulation of the core pre-mRNA splicing machinery by MYC and PRMT5 is essential to sustain lymphomagenesis [fetal liver]
Over-expressed MYC binds to virtually all active promoters within a cell, although with different binding affinities, and modulates gene expression, both positively and negatively. Here, we show that during lymphomagenesis in Eµ-myc transgenic mice, MYC directly up-regulates the transcription of the...
ORGANISM(S): Mus musculus 
2015-05-19 | E-GEOD-61637 | biostudies-arrayexpress
GenomicsEnhancer Sequence Variants and Transcription Factor Deregulation Synergize to Construct Pathogenic Regulatory Circuits in B Cell Lymphoma (ChIP-Seq, FAIRE-Seq)
Most B cell lymphomas arise in the germinal center (GC), where humoral immune responses evolve from potentially oncogenic cycles of mutation, proliferation, and clonal selection. Although lymphoma gene expression diverges significantly from GC-B cells, underlying mechanisms that alter the activities...
ORGANISM(S): Homo sapiens 
2015-01-15 | E-GEOD-62245 | biostudies-arrayexpress
TranscriptomicsGene Expression profiling of Myc-induced lymphomagenesis
The ability of oncogenes to provoke cancer is harnessed by regulators that control cell proliferation or induce apoptosis, and bypass of these checkpoints is a hallmark of malignancies. Myc oncoproteins are overexpressed in ~70% of all cancers and induce numerous transcription targets that regulate ...
ORGANISM(S): Mus musculus 
2011-10-31 | E-GEOD-32239 | biostudies-arrayexpress
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