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TranscriptomicsTranscription profiling by array of 4T1 murine breast carcinoma cells and derived cell lines resistant to photodynamic therapy induced by novel porphyrin-based photosensitizers and temoporfin
The efficacy of photodynamic therapy for treating premalignant and malignant tumors is often limited by the emerging resistant tumor cells. We have developed experimental model systems to study the mechanisms associated with resistance to photodynamic therapy induced by structurally similar photosen...
ORGANISM(S): Mus musculus 
2017-06-14 | E-MTAB-5082 | biostudies-arrayexpress
TranscriptomicsDeterminants of excess genetic risk of acute myocardial infarction M-bM-^@M-^S a matched case-control study
Peripheral blood samples of patients with acute myocardial infarction were matched with those of control patients to identify possible differences in corresponding gene expression profiles. The controls were matched to cases based on gender, age, status of diabetes mellitus and smoking status. Six m...
ORGANISM(S): Homo sapiens 
2014-12-05 | E-GEOD-34198 | biostudies-arrayexpress
UnknownBinding of the peptide deformylase on the ribosome surface modulates the exit tunnel interior.
Not available
S-EPMC9748369 | biostudies-literature
TranscriptomicsModification of Disp3 expression levels by CRISPR/Cas9 technology affects neural stem cells capacity to differentiate.
DISP3 (PTCHD2), a sterol-sensing domain-containing protein, is highly expressed in neural tissue but its role in neural differentiation is unknown. To determine the effect of DISP3 on neural stem cells phenotype of NS-5 cells, we impaired Disp3 gene using CRISPR/Cas9 technology. Modification of Disp...
ORGANISM(S): Mus musculus 
2017-02-17 | E-MTAB-4485 | biostudies-arrayexpress
TranscriptomicsEffect of simvastatin on pancreatic cancer cells
The aim of our study was to assess the impact of simvastatin on the amount of cytosolic lipid droplets (LDs), which are implicated in many biological processes including proliferation, inflammation, carcinogenesis, apoptosis, necrosis or growth arrest. Human pancreatic cancer cells MiaPaCa-2 were t...
ORGANISM(S): Homo sapiens 
2013-11-21 | E-MTAB-1501 | biostudies-arrayexpress
TranscriptomicsMicroenvironment-driven resistance to B-Raf inhibition in a melanoma patient is accompanied by broad changes of gene methylation and expression in distal fibroblasts. Genome methylation study.
In this study, we compared gene expression and genome methylation of diverse fibroblast populations from a patient suffering from acrolentiginous melanoma (Breslow 4.0 mm, Clark IV, B-Raf V600E mutated). Stromal cells from the metastasis, i.e., melanoma associated fibroblasts (MAF), were positive fo...
ORGANISM(S): Homo sapiens 
2018-12-30 | E-MTAB-4965 | biostudies-arrayexpress
TranscriptomicsExpression profiling of murine E10.5 TLR2+ CD11b+ embryonic phagocytes by comparative microarray analyses
The detection of Toll-like receptor 2 (TLR2) expression on E10.5 early embryonic phagocytes prompted us to determine the list of markers co-expressed with TLR2 in a cell-type specific manner. Thus, a comparative expression profiling of cDNAs between murine E10.5 TLR2+ CD11b+ embryonic cells and TLR2...
ORGANISM(S): Mus musculus 
2014-12-01 | E-MTAB-1537 | biostudies-arrayexpress
TranscriptomicsFibroblasts prepared from stroma of basal cell carcinoma in comparison to normal dermal fibroblasts
Adult tissue stem cells are known to participate in cancer formation. Indeed, cells exhibiting markers of embryonic stem cells such as Oct-4 and Nanog were detected in some malignant tumors. In this study we demonstrated that stromal cells prepared from the basal cell carcinoma are able to induce ex...
ORGANISM(S): Homo sapiens 
2011-11-02 | E-MTAB-272 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat 3 months old male Wistar animals by aorto-caval fistula reveals alterations in systemic substrate metabolism in rat volume-overload model of chronic heart failure
Abnormalities in metabolism of energetic substrates may play a role in progression of chronic heart failure (HF). The goal of the study was to examine the extent and mechanisms of metabolic alterations in rat model of chronic HF due to volume overload. Volume overload was induced in 3 months old mal...
ORGANISM(S): Rattus norvegicus 
2011-10-05 | E-MTAB-190 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human neural crest-originated stem cells, BLM melanoma cell line and neonatal highly pigmented melanocytes to study their production of extracellular factors.
Analysis of microarrays with transcriptome of human neural crest-originated stem cells (NCSC), highly metastatic BLM melanoma cell line and neonatal highly pigmented melanocytes (HPM) at whole genome scale demonstrated distinct differences among tested cell types.
ORGANISM(S): Homo sapiens 
2015-12-09 | E-MTAB-2401 | biostudies-arrayexpress
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