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TranscriptomicsSingle cell mRNA -sequencing reveals cell-to-cell variation in three mouse ES cell culture conditions
We sequence mRNA from single mESCs from three culture conditions: serum + LIF, 2i + LIF and alternative 2i + LIF. We extensively analysed population and single cell gene expression to identify differences and similarities between conditions. This is a subset of data from ArrayExpress accession E-ERA...
ORGANISM(S): Mus musculus 
2016-01-22 | E-MTAB-2600 | biostudies-arrayexpress
TranscriptomicsRNA-seq of dendritic cells isolated from normoglycemic and hyperglycemic mice
This study aims to understand the role of high blood glucose on the immune response
ORGANISM(S): Mus musculus 
2026-02-02 | E-MTAB-16290 | biostudies-arrayexpress
GenomicsChromatin profiling of dendritic cells in healthy and hyperglycaemic mice
The aim of the experiment was to compare chromatin states between healthy and hyperglycaemic mice. We focused on dendritic cells extracted from the lungs. Nuclei were extracted from 200.000 sorted dendritic cells per sample. H3K27me3 and H3K27ac were then profiled using CUT&RUN protocol.
ORGANISM(S): Mus musculus 
2023-06-29 | E-MTAB-11390 | biostudies-arrayexpress
TranscriptomicsThe impact of microbial colonisation on intestinal macrophages
In this study we compared three different groups of mice to understand the role of antibiotics and microbial colonisation during early life. (1) young mice that were untreated and sacrificed pre-weaning, 12 days after birth, (2) control mice were also untreated and sacrificed 44 days after birth, th...
ORGANISM(S): Mus musculus 
2026-07-18 | E-MTAB-14263 | biostudies-arrayexpress
TranscriptomicsRegulation of transcriptional states in acute liver failure by microbiome
We performed single cell RNAseq of liver cells in acute liver failure model in mice with different microbiome states to unravel cellular changes in the disease and the impact of gut microbiota on the physiology in this disease.
ORGANISM(S): Mus musculus 
2020-08-18 | E-MTAB-8263 | biostudies-arrayexpress
Transcriptomicssingle cell RNA sequencing of liver cells in TREM2 KO mice
The goal of this study is to understand the effect of fibrosis on the cell frequencies and gene expression in liver in Trem2KO mice. To achieve that we performed single cell sequencing of liver cells from whole-body Trem2 KO mice treated with thioacetamide to induce liver fibrosis.
ORGANISM(S): Mus musculus 
2026-01-01 | E-MTAB-14253 | biostudies-arrayexpress
Transcriptomicssingle cell RNA sequencing of liver cells in KLF9 and TSC22d1 knock-out mice
This study aims to understand the effect of fibrosis on the cell frequencies and gene expression in liver in stellate cell-specific Klf9 and Tsc22d1 knock-out mice. To achieve that we performed single-cell sequencing of liver cells from mice treated with thioacetamide to induce liver fibrosis.
ORGANISM(S): Mus musculus 
2026-01-01 | E-MTAB-14254 | biostudies-arrayexpress
TranscriptomicsThe host & gut microbiome orchestrate smoking cessation-induced weight gain
To elucidate the potential impact of smoking cessation weight gain associated metabolites on adipose tissue cellular and gene-expression immune program, we performed single cell transcriptomic analysis of immune cells of epididymal adipose tissue in DMG- and ACG-supplemented mice and their respectiv...
ORGANISM(S): Mus musculus 
2021-11-22 | E-MTAB-10869 | biostudies-arrayexpress
TranscriptomicsTh single cell RNA-Seq
Th2 cells regulate helminth infections, allergic disorders, tumor immunity and pregnancy by secreting various cytokines. It is likely that there are undiscovered Th2-signaling molecules. While steroids are known to be immunoregulators, de novo steroid production from immune cells has not been previo...
ORGANISM(S): Mus musculus 
2014-04-25 | E-MTAB-2512 | biostudies-arrayexpress
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