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ProteomicsA Rapid and Sensitive Single-cell Proteomic Method Based on Fast LC Separation, Deep-learning RT Prediction and MS1-only Acquisition
We report an integrate strategy that combines fast liquid chromatography (LC) separation, deep learning-based retention time (RT) prediction and MS1-only acquisition for sensitive and rapid single-cell proteome analysis. Finally, SCP-MS1 was applied to sorafenib resistant HepG2 cells.
ORGANISM(S): Homo Sapiens 
PXD036211 |
ProteomicsIdentification of N-Glycopeptides based on Glycocarrier Strategy
In this work, we developed a glycocarrier strategy to amplify MS signals with isobaric labeling for highly sensitive intact N-glycopeptide characterization from single and small numbers of cells without enrichment. Successful application in cell lines and microglia from the regional mouse brain demo...
ORGANISM(S): Homo Sapiens Mus Musculus 
2022-11-18 | PXD038212 |
ProteomicsIdentification of p72-interacting proteins in porcine alveolar macrophages
To explore the potential mechanisms regulating p72 stability, we performed co-immunoprecipitation using an anti-p72 antibody in ASFV-infected PAMs, followed by mass spectrometry analysis to identify host factors interacting with p72.
ORGANISM(S): Sus Scrofa Domesticus 
2026-01-18 | PXD073232 |
ProteomicsTargeting endoplasmic reticulum-anchored CRTH2 binding to LARP6 ameliorates organ fibrosis
Excessive deposition of extracellular matrix, mainly collagen protein, is the hallmark of organ fibrosis. The molecular mechanisms of the regulation of fibrotic protein biosynthesis are unclear. Here, we found that chemoattractant receptor homologous molecule expressed on TH2 cells (CRTH2), a cell m...
ORGANISM(S): Mus Sp. 
PXD025610 |
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