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TranscriptomicsCellular reprogramming by the conjoint action of ERalpha, FOXA1, and GATA3 to a ligand inducible growth state
Despite the role of the estrogen receptor alpha (ERalpha) pathway as a key growth driver for breast cells, the phenotypic consequence of exogenous introduction of ERalpha into ERalpha-negative cells paradoxically has been growth inhibition. We map the binding profiles of ERalpha and its interacting ...
ORGANISM(S): Homo sapiens 
2011-09-04 | E-GEOD-30574 | biostudies-arrayexpress
GenomicsCellular reprogramming by the conjoint action of ERalpha, FOXA1 and GATA3 to a ligand-inducible growth state
Despite the role of the estrogen receptor alpha (ERalpha) pathway as a key growth driver for breast cells, the phenotypic consequence of exogenous introduction of ERalpha into ERalpha-negative cells paradoxically has been growth inhibition. We map the binding profiles of ERalpha and its interacting ...
ORGANISM(S): Homo sapiens 
2011-09-05 | E-GEOD-29073 | biostudies-arrayexpress
GenomicsIntegrative model of genomic factors for determining binding site selection by estrogen receptor alpha in MCF-7 cancer cells
Using the estrogen receptor alpha (ERalpha) as a model ligand inducible transcription factor, we sought to explicitly define parameters that determine transcription factor binding site selection on a genomic scale in an inducible system that minimizes confounding chromatin effects by the transcripti...
ORGANISM(S): Homo sapiens 
2011-01-25 | E-GEOD-26831 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array time series of human MCF7 breast cancer cells treated with estradiol
Using a chromatin immunoprecipitation-paired end diTag cloning and sequencing strategy, we mapped estrogen receptor alpha (ERalpha) binding sites in MCF-7 breast cancer cells. We identified 1,234 high confidence binding clusters of which 94% are projected to be bona fide ERalpha binding regions. Onl...
ORGANISM(S): Homo sapiens 
2009-01-09 | E-GEOD-11352 | biostudies-arrayexpress
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