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UnknownPhosphorylation of Yun is required for stem cell proliferation and tumorigenesis.
Not available
S-EPMC9136491 | biostudies-literature
Proteomicsp38β-mediated BiP phosphorylation drives stemness and chemoresistance by suppressing UPR activation in hepatocellular carcinoma
Increasing evidence has demonstrated that tumor-initiating cells (TICs) contribute to tumor initiation and therapy resistance through dysregulation of kinase signaling. However, the intertwined networks of many kinases and their functional downstream targets are yet to be revealed and fully characte...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD067039 | Pride
Mapk11 Bip 
ProteomicsBroad-spectrum kinome profiling identifies CDK6 upregulation as a driver of lenvatinib resistance in hepatocellular carcinoma
Lenvatinib is the FDA-approved targeted drug for advanced hepatocellular carcinoma (HCC), but the efficacy is modest due to drug resistance. Tumor kinome re-wiring governs drug resistance in resistant cancer cells, which is an obstacle for efficient cancer therapy. Therefore, identification the kina...
ORGANISM(S): Homo sapiens (Human) 
2023-09-29 | PXD038152 | Pride
Beta-catenin Cancer stemness Hcc Cdk6 Lenvatinib 
UnknownClathrin light chain A facilitates small extracellular vesicle uptake to promote hepatocellular carcinoma progression.
Not available
S-EPMC10660914 | biostudies-literature
UnknownCrystal-Phase-Selective Etching of Heterophase Au Nanostructures.
Not available
S-EPMC11579570 | biostudies-literature
UnknownDigital Rehabilitation Program for Breast Cancer Survivors on Adjuvant Hormonal Therapy: A Feasibility Study.
Not available
S-EPMC11639799 | biostudies-literature
UnknownNHE7 upregulation potentiates the uptake of small extracellular vesicles by enhancing maturation of macropinosomes in hepatocellular carcinoma.
Not available
S-EPMC10876205 | biostudies-literature
ProteomicsPatient-derived extracellular vesicles drive cancer stemness and tumorigenesis in hepatocellular carcinoma via polymeric immunoglobulin receptor
Background & Aims: Extracellular vesicles (EVs) play a pivotal role in connecting tumor cells and their local and distant microenvironment. Here, we aimed to understand the role and molecular basis of patient-derived EVs in modulating cancer stemness and tumorigenesis in the context of hepatocellula...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD025522 | Pride
Hcc Evs Shotgun proteomics 
UnknownGenome-Wide Association Studies of HIV-1 Host Control in Ethnically Diverse Chinese Populations.
Not available
S-EPMC4454153 | biostudies-literature
UnknownCharacterization of Volatile Organic Compounds and Aroma Sensory Properties in Yunnan Cigar.
Not available
S-EPMC11498996 | biostudies-literature
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