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ProteomicsQuantitative mapping of proteome dynamics during polarization of human iPSC-derived neurons
Early neuronal development is a well-coordinated process in which neuronal stem cells differentiate into polarized neurons. This process has been well studied in classical non-human model systems, but to what extent this is recapitulated in human neurons remains unclear. To study neuronal polarizati...
ORGANISM(S): Homo sapiens (Human) 
2020-11-17 | PXD020227 | Pride
Human neurons Differentiation Hipsc Npc 
ProteomicsCentrosome-mediated microtubule remodeling during axon formation in human iPSC-derived neurons
Local microtubule remodeling is critical for axon formation, the first step in establishing neuronal polarity. However, the function of the microtubule organizing centrosomes during the onset of axon formation, is still under debate. Here, we demonstrate that centrosomes play an essential role in co...
ORGANISM(S): Homo sapiens (Human) 
2021-02-12 | PXD020221 | Pride
Centrosome  axon  development  human  hipsc-derived neuron 
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