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TranscriptomicsSingle cell expression analysis of Defa6+ cells possessing either wild-type Tcf4 or homozygous loss of the Tcf4 protein isolated from mouse small intestinal epithelium
The T-cell factor 4 (Tcf4) protein (encoded by the Tcf7l2 gene) is a nuclear transcription regulator, which plays a key role in maintaining intestinal homeostasis, stem cell self-renewal and epithelial cell differentiation. Tcf4 has been identified as a crucial regulator of Paneth cell function in s...
ORGANISM(S): Mus musculus 
2026-06-29 | E-MTAB-14489 | biostudies-arrayexpress
TranscriptomicsExpression profiling of Defa6+ cells isolated from Apc-deficient colon tumor using single-cell RNA-Seq
Aberrant activation of the canonical Wnt pathway underlines the development and growth of intestinal tumors. The Apc-min (multiple intestinal neoplasia) mouse strain carries a single nucleotide mutation in one allele of the Apc tumor suppressor gene. Random deactivation of the second allele occurs d...
ORGANISM(S): Mus musculus 
2025-04-01 | E-MTAB-13752 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-Seq expression profiling of RFP-positive cells isolated from Ki67-RFP/Tcf7l2/Villin-CreERT2 mouse small intestinal epithelium 7 days after tamoxifen administration
The T-cell factor 4 (Tcf4) protein (encoded by the Tcf7l2 gene) is a nuclear transcription regulator, which plays a key role in maintaining intestinal homeostasis, stem cell self-renewal and epithelial cell differentiation. Tcf4 has been identified as a key regulator of Paneth cell function in small...
ORGANISM(S): Mus musculus 
2026-06-29 | E-MTAB-13731 | biostudies-arrayexpress
TranscriptomicsSingle cell expression profiling of murine subventricular zone in adult brain three days after focal celebral ischemia
Ischemic stroke is a serious medical condition that leads to the onset of neurological symptoms such as loss of motor and cognitive functions. Focal cerebral ischemia (FCI) occurs due to the interrupted blood supply to the site of injury, resulting in the demise of brain cells. The subventricular zo...
ORGANISM(S): Mus musculus 
2021-01-01 | E-MTAB-9935 | biostudies-arrayexpress
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