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TranscriptomicsThe Sp100 component of ND10/PML bodies is a potent tumor suppressor
The Sp100 component of ND10/PML bodies is a potent tumor suppressor: accelerated senescence and rapid malignant transformation of human fibroblasts through modulation of an embryonic stem cell program. Identifying the functions of proteins, which define specific subnuclear structures and territorie...
ORGANISM(S): Homo sapiens 
2012-12-04 | E-GEOD-20613 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiles in Peripheral Blood Mononuclear Cells Can Distinguish Patients with NonSmall Cell Lung Cancer.
We report a 29-gene diagnostic signature, which distinguishes individuals with NSCLC from controls with non-malignant lung disease with 91% Sensitivity, 79% Specificity and a ROC AUC of 92%. Accuracy on an independent set of 18 NSCLC samples from the same location was 79%. Samples from an independe...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-13255 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of PBMC from HIV and HIV/TB co-infected patients
Diagnosis of TB, especially in the presence of an HIV co-infection, can be challenging when using conventional diagnostic methods. In this study, we analyzed global gene expression data from PBMC of patients that were either mono-infected with HIV or co-infected with HIV and TB in order to identify...
ORGANISM(S): Homo sapiens 
2014-03-05 | E-GEOD-50834 | biostudies-arrayexpress
TranscriptomicsDivergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis
Combinatorial actions of relatively few transcription factors control hematopoietic differentiation. To investigate this process in erythro-megakaryopoiesis, we correlated the genome-wide chromatin occupancy signatures of four master hematopoietic transcription factors (GATA1, GATA2, TAL1, and FLI1)...
ORGANISM(S): Mus musculus 
2014-11-14 | E-GEOD-51337 | biostudies-arrayexpress
TranscriptomicsComparison between HuT78 parental and romidpepsin-selected cell lines
Gene expression values were determined for HuT78 parental cells and cells selected with romidpesin in the presence of P-glycoprotein inhibitors. HuT78 DpVp35 cells are maintained in 35 ng/ml romidepsin with 2.5 µg/ml verapamil and HuT78 DpP100 cells are maintained in 100 ng/ml romidepsin with 1 µM v...
ORGANISM(S): Homo sapiens 
2013-03-12 | E-GEOD-45018 | biostudies-arrayexpress
TranscriptomicsLong noncoding RNA expression in several hematopoietic progenitor and differentiated cell populations using a custom Agilent microarray
Mammals express thousands of long noncoding (lnc) RNAs, a few of which are shown to function in tissue development. However, the entire repertoire of lncRNAs and the extent to which they regulate biological processes in different tissues and species are not defined. Indeed, most lncRNAs are not cons...
ORGANISM(S): Mus musculus 
2014-02-20 | E-GEOD-51892 | biostudies-arrayexpress
TranscriptomicsDNA methylation analysis of PBMC from HIV and HIV/TB co-infected patients
Genome wide DNA methylation profiling of PBMC from South African patients either infected with HIV only or coinfected with HIV and tuberculosis (TB). The Illumina Infinium 27k Human DNA methylation Beadchip was used to obtain DNA methylation profiles from PBMC samples. Samples included 19 HIV patien...
ORGANISM(S): Homo sapiens 
2014-03-05 | E-GEOD-50835 | biostudies-arrayexpress
TranscriptomicsDivergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis
Combinatorial actions of relatively few transcription factors control hematopoietic differentiation. To investigate this process in erythro-megakaryopoiesis, we correlated the genome-wide chromatin occupancy signatures of four master hematopoietic transcription factors (GATA1, GATA2, SCL/TAL1 and FL...
ORGANISM(S): Mus musculus 
2013-08-09 | E-GEOD-49664 | biostudies-arrayexpress
TranscriptomicsFoxp1 is a rate-limiting and essential negative regulator of Tfh cell differentiation
CD4+ T follicular helper (Tfh) cells are essential for germinal center (GC) and high-affinity antibody responses. Yet the regulation that determines the initial development of Tfh cells is still largely unknown. Here we find that transcription factor Foxp1, previously shown to be essential in mainta...
ORGANISM(S): Mus musculus 
2014-05-18 | E-GEOD-50725 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human gastrointestinal stromal tumour is predictive of rapid response to imatinib mesylate
Gene expression profiling using oligonucleotide microarrays performed on tumor samples obtained before and after imatinib mesylate (IM) therapy. Rapid responding (to IM) samples were compared to non-responding/stable disease samples as measured by CT scan measurements to identify a gene signature t...
ORGANISM(S): Homo sapiens 
2009-12-02 | E-GEOD-15966 | biostudies-arrayexpress
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