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ProteomicsTargeting KPNB1 suppresses DNA damage repair in AML cells by inhibiting HMGB2 nuclear translocation
To gain insight into the potential cargo proteins mediated by KPNB1, the nuclear fraction of DMSO- and IPZ-treated NB-4 cells were isolated and then subjected to mass spectrometry analysis.
ORGANISM(S): Homo sapiens (Human) 
2025-01-03 | PXD056172 | Pride
Kpnb1 Nb-4 
GenomicsEffect of pharmacologic inhibition of KPNB1 by Importazole on gene expression of NB-4 cells
Effect of pharmacologic inhibition of KPNB1 by Importazole on gene expression of NB-4 cells
PRJNA1164748 | ENA
TranscriptomicsEffect of pharmacologic inhibition of KPNB1 by Importazole on gene expression of NB-4 cells
Acute myeloid leukemia (AML) is the most common malignancy of the hematologic system with refractory relapse and limited treatments. Nucleocytoplasmic trafficking of biomolecules mediated by Karyopherin proteins plays vital roles in AML promotion and development, but the underlying mechanism is not ...
ORGANISM(S): Homo sapiens 
2025-01-08 | GSE277912 | GEO
UnknownKPNB1 mediates PER/CRY nuclear translocation and circadian clock function.
Not available
S-EPMC4597257 | biostudies-literature
UnknownKPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells.
Not available
S-EPMC5978811 | biostudies-literature
UnknownStabilization of KPNB1 by deubiquitinase USP7 promotes glioblastoma progression through the YBX1-NLGN3 axis.
Not available
S-EPMC11040697 | biostudies-literature
UnknownEZH2-miR-30d-KPNB1 pathway regulates malignant peripheral nerve sheath tumour cell survival and tumourigenesis.
Not available
S-EPMC4166508 | biostudies-literature
UnknownDecreased KPNB1 Expression is Induced by PLK1 Inhibition and Leads to Apoptosis in Lung Adenocarcinoma.
Not available
S-EPMC5706017 | biostudies-literature
GenomicsGenomic and transcriptomic data analyses highlight KPNB1 and MYL4 as novel risk genes for congenital heart disease
Genomic and transcriptomic data analyses highlight KPNB1 and MYL4 as novel risk genes for congenital heart disease
PRJNA799052 | ENA
UnknownKPNB1 modulates the Machado-Joseph disease protein ataxin-3 through activation of the mitochondrial protease CLPP.
Not available
S-EPMC9259533 | biostudies-literature
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