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ProteomicsADAMTS12 serves as a checkpoint in fibrosis that controls migration and expansion of injury-responsive fibroblasts
Fibrosis represents the uncontrolled replacement of parenchymal tissue with extracellular matrix (ECM) produced by myofibroblasts. While genetic fate-tracing and single-cell RNA-sequencing (scRNA-seq) technologies have helped elucidate fibroblast heterogeneity and ontogeny beyond fibroblast to myofi...
ORGANISM(S): Homo sapiens (Human) 
2024-07-01 | PXD040152 | Pride
Fibrosis Adamts12 Extracellular matrix 
MetabolomicsDynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression

Metabolic reprogramming is critical for tumor initiation and progression. However, the exact impact of specific metabolic changes on cancer progression is poorly understood. Here, we integrate multimodal analyses of primary and metastatic clonally-related clear cell renal cancer cells (ccRCC) gro...

2022-12-08 | MTBLS5615 | MetaboLights
ProteomicsSenescence of endothelial cells promotes phenotypic changes in adventitial fibroblasts: possible implications for vascular aging
Aging is the most important risk factor for the development of cardiovascular diseases. Senescent cells release plethora of factors commonly known as the senescence-associated secretory phenotype (SASP), which can modulate the normal function of the vascular wall. It is currently not well understood...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-02-13 | MSV000094069 | MassIVE
Genomicsena-DATASET-IJC-07-11-2014-17:58:39:549-794 - samples
Cancer exome reads consisting of FASTQ paired end reads from bone marrow samples
EGAD00001001058 | EGA
GenomicsMDS Sequencing Project Cancer Cell
Myelodysplastic syndromes (MDS) are uncommon entities, heterogeneous clinically and cytogenetically. The aim of the present study is to determine genetic alteration in this subset of patients. Expected results: Identification of new aberrations and genetic markers in order to detect novel genes invo...
EGAS00001001011 | EGA
GenomicsIJC Myelodysplastic Syndromes Sequencing Group
Data Access Committee EGAC00001000257
EGAC00001000257 | EGA
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