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ProteomicsADAMTS12 serves as a checkpoint in fibrosis that controls migration and expansion of injury-responsive fibroblasts
Fibrosis represents the uncontrolled replacement of parenchymal tissue with extracellular matrix (ECM) produced by myofibroblasts. While genetic fate-tracing and single-cell RNA-sequencing (scRNA-seq) technologies have helped elucidate fibroblast heterogeneity and ontogeny beyond fibroblast to myofi...
ORGANISM(S): Homo sapiens (Human) 
2024-07-01 | PXD040152 | Pride
Fibrosis Adamts12 Extracellular matrix 
ProteomicsADAMTS7, a target in atherosclerosis, cooperates with homolog ADAMTS12 to protect against myxomatous valve degeneration
The metalloprotease ADAMTS7, a drug target in atherosclerosis and vascular restenosis, is thought to have no relevant physiological role in the cardiovascular system. However, potential cooperation with its close homolog, ADAMTS12, that may mask such a role remains unexplored. The objective of the p...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-05-07 | PXD055550 | Pride
Metalloproteinase Hypertrophy Chondroitin sulfate Heart valve Fibrosis Adamts Regurgitation Extracellular matrix Myxomatous valve 
UnknownADAMTS12, a new candidate gene for pediatric stroke.
Not available
S-EPMC7446847 | biostudies-literature
UnknownEpigenetic regulatory mechanism of ADAMTS12 expression in osteoarthritis.
Not available
S-EPMC10318776 | biostudies-literature
TranscriptomicsExpression data from untreated and DSS-treated Adamts12 WT and KO mice
Adamts12-deficient mice undergo more severe colitis than WT mice after induction with DSS. We used microarrays to determine the gene expression differences between Adamts12-deficient and WT mice during ulcerative colitis induced with DSS (dextran sodium sulfate)
ORGANISM(S): Mus musculus 
2012-09-01 | GSE40529 | GEO
TranscriptomicsExpression data from untreated and DSS-treated Adamts12 WT and KO mice
Adamts12-deficient mice undergo more severe colitis than WT mice after induction with DSS. We used microarrays to determine the gene expression differences between Adamts12-deficient and WT mice during ulcerative colitis induced with DSS (dextran sodium sulfate) Fragments of distal colon from DSS-tr...
ORGANISM(S): Mus musculus 
2012-09-01 | E-GEOD-40529 | biostudies-arrayexpress
UnknownEffects of metalloprotease ADAMTS12 on cervical cancer cell phenotype and its potential mechanism.
Not available
S-EPMC10465472 | biostudies-literature
UnknownADAMTS12 acts as a tumor microenvironment related cancer promoter in gastric cancer.
Not available
S-EPMC8154915 | biostudies-literature
UnknownADAMTS7, a target in atherosclerosis, cooperates with its homolog ADAMTS12 to protect against myxomatous valve degeneration.
Not available
S-EPMC11925103 | biostudies-literature
UnknownAK001058 promotes the proliferation and migration of colorectal cancer cells by regulating methylation of ADAMTS12.
Not available
S-EPMC6789239 | biostudies-literature
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