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ProteomicsWDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling
The endosomal FYVE- and WD40-domain-containing protein WDFY2 has been assigned a function as tumor suppressor, but its functional mechanism has remained elusive. Here we have used confocal, widefield and super-resolution fluorescence microscopy to show that WDFY2 localizes to the base of retromer-co...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-07-23 | MSV000084122 | MassIVE
TranscriptomicsProteolytic inactivation of the autoinhibitory prodomain is essential for the pro-tumorigenic function of membrane type-1 matrix metalloproteinase (MT1-MMP)
Invasive cancers employ pericellular proteolysis to breach the extracellular matrix and basement membrane barriers and invade the surrounding tissue. Pro-invasive, pro-tumorigenic MT1-MMP is the primary mediator of proteolytic events on the cancer cell surface. Cellular MT1-MMP is synthesized as a l...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-28655 | biostudies-arrayexpress
TranscriptomicsEpidermal cells help coordinate leukocyte migration during inflammation through fatty acid-fueled matrix metalloproteinase production
In addition to satisfying the metabolic demands of cells, mitochondrial metabolism helps regulate immune cell function. To date, such cell-intrinsic metabolic-immunologic cross-talk has only been described operating in cells of the immune system. Here we show that epidermal cells utilize fatty acid ...
ORGANISM(S): Danio rerio 
2014-04-01 | E-GEOD-56365 | biostudies-arrayexpress
TranscriptomicsColonic gene expression data of TIMP1 knock out colitis mice
Increased levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) have been detected in fibrotic strictures in Crohn’s disease. In a murine model of chronic inflammation, fibrosis was associated with an increase in TIMP-1 and inhibition of matrix metalloproteinase (MMP)-mediated degradation. We...
ORGANISM(S): Mus musculus 
2016-07-22 | E-GEOD-73424 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation identifies trophoblast invasion-related genes: Claudin-4 and Fucosyltransferase IV control mobility via altering matrix metalloproteinase activity
Previously we have shown that extravillous cytotrophoblast (EVT) outgrowth and migration on a collagen gel explant model were restricted by exposure to decidual natural killer cells (dNK). This study investigates the molecular causes behind this phenomenon. Genome wide DNA methylation of exposed and...
ORGANISM(S): Homo sapiens 
2015-04-07 | E-GEOD-60885 | biostudies-arrayexpress
TranscriptomicsIncreased plasma matrix metalloproteinase 1 is associated with the presence of esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) patients are usually diagnosed at late stages, prohibiting the chance of surgical cure. The obstacle partly comes from the lack of molecular markers for early detection. Moreover, there is no consensus about endoscopic surveillance for ESCC. This study aimed...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-70409 | biostudies-arrayexpress
Proteomicsintracellular MMP-2 proteolysis in cardiac tissue
Induced proteolysis of rat heart extracts with recombinant MMP-2 followed by subtiligase-N-terminomics
ORGANISM(S): Rattus (ncbitaxon:10114) 
2023-11-01 | MSV000093229 | MassIVE
GenomicsPeripheral immune-derived matrix metalloproteinase promotes stress susceptibility
Peripheral immune-derived matrix metalloproteinase promotes stress susceptibility
PRJNA836902 | ENA
TranscriptomicsMatrix metalloproteinase-3 mediates cardiac differentiation of mouse embryonic stem cells
Recently, it was shown that the Bmp antagonist Noggin could strongly induce cardiomyocyte differentiation by transient treatment of undifferentiated ES cells. In order to determine how Noggin may induce cardiac differentiation, we compared differentially expressed genes during Noggin treatment of ES...
ORGANISM(S): Mus musculus 
2007-12-18 | GSE8328 | GEO
ProteomicsSubstrate profiling of the metalloproteinase ovastacin – Implications for its physiological function in mammalian fertilization
The metalloproteinase ovastacin is released by the mammalian oocyte upon fertilization and cleaves zona pellucida protein 2, a component of the surrounding extracellular matrix, at a distinct cleavage site. This limited proteolysis hardens the zona pellucida, abolishes sperm binding and thereby regu...
ORGANISM(S): Mus Musculus (mouse) 
2023-09-15 | PXD038561 | JPOST Repository
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