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TranscriptomicsSynthetic Lethal Interaction Between Oncogenic KRAS Dependency and Suppression of STK33 in Human Cancer Cells
Many human oncogenes are challenging therapeutic targets. An alternative to direct targeting of oncogenes is to perform â??synthetic lethalityâ?? screens for genes that are essential only in the context of specific cancer-causing mutations. We used high-throughput RNA interference (RNAi) to identify...
ORGANISM(S): Homo sapiens 
2009-06-24 | E-GEOD-15151 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lung epithelial cells ollowing oncogenic KRAS expression and TBK1 suppression or infection with oncogenic KRAS (G12V) - SuperSeries
The proto-oncogene KRAS is mutated in a wide array of human cancers, most of which are aggressive and respond poorly to standard therapies. Although the identification of specific oncogenes has led to the development of clinically effective, molecularly targeted therapies in some cases, KRAS has rem...
ORGANISM(S): Homo sapiens 
2009-10-31 | E-GEOD-17672 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human immortalized lung epithelial cells following infection with oncogenic KRAS (G12V)
The purpose of the dataset is to analyze expression of genes induced by KRAS; The proto-oncogene KRAS is mutated in a wide array of human cancers, most of which are aggressive and respond poorly to standard therapies. Although the identification of specific oncogenes has led to the development of cl...
ORGANISM(S): Homo sapiens 
2009-10-31 | E-GEOD-17671 | biostudies-arrayexpress
ProteomicsHuman colon cancer cell lines - LC-MSMS
Despite the advent of mutant-selective KRAS inhibitors, colorectal cancer (CRC) responses remain limited, with frequent stable disease and rapid recurrence. The mechanisms underlying CRC tolerance to KRAS inhibition and eventual resistance are poorly understood. Here, we explored early transcription...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD059013 | Pride
Human Lc-msms Resistant Colon cancer Kras silencing 
TranscriptomicsTranscription profiling of immortalized human lung epithelial cells following oncogenic KRAS expression and TBK1 suppression
The purpose of the dataset is to analyze expression of genes induced by KRAS and regulated by TBK1; The proto-oncogene KRAS is mutated in a wide array of human cancers, most of which are aggressive and respond poorly to standard therapies. Although the identification of specific oncogenes has led to...
ORGANISM(S): Homo sapiens 
2009-11-15 | E-GEOD-17643 | biostudies-arrayexpress
GenomicsDifferential unfolded protein response regulation in KRAS silencing sensitive versus innately resistant colorectal cancer cells [HCT116]
Differential unfolded protein response regulation in KRAS silencing sensitive versus innately resistant colorectal cancer cells [HCT116]
PRJNA1072042 | ENA
GenomicsDifferential unfolded protein response regulation in KRAS silencing sensitive versus innately resistant colorectal cancer cells [LS174T]
Differential unfolded protein response regulation in KRAS silencing sensitive versus innately resistant colorectal cancer cells [LS174T]
PRJNA1072041 | ENA
TranscriptomicsThe RALA pathway can maintain the proliferation of KRAS- and BRAF-mutated cancer cells
By silencing of RALA, a downstream member of the RAS signal transduction pathway, we aimed to determine whether genes downstream of a mutated KRAS (codon 12 or 13) or a mutated BRAF can have significant functions in colorectal cancer carcinogenesis. RALA was silenced in three colorectal cancer cell ...
ORGANISM(S): Homo sapiens 
2015-06-20 | E-GEOD-39857 | biostudies-arrayexpress
GenomicsDifferential unfolded protein response regulation in KRAS silencing sensitive versus innately resistant colorectal cancer cells [SW480 and SW837]
Differential unfolded protein response regulation in KRAS silencing sensitive versus innately resistant colorectal cancer cells [SW480 and SW837]
PRJNA1195348 | ENA
GenomicsMurine Kras mutant or Kras wildtype cancer cell lines
Murine Kras mutant or Kras wildtype cancer cell lines
PRJNA540827 | ENA
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