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MetabolomicsTargeting GSTZ1 sensitizes KRASG12C-mutant lung cancer cells by overcoming glutathione and glycolysis pathway rewiring

KRAS mutations are prevalent in lung cancer, but KRAS G12C inhibitors exhibit limited efficacy, partly due to metabolic adaptations, such as enhanced glutathione metabolism and increased glycolysis. Glutathione S-Transferase Zeta 1 (GSTZ1) is a metabolic enzyme that regulates cell metabolism. How...

2026-05-15 | MTBLS12791 | MetaboLights
TranscriptomicsProgressive genomic instability in the FVB/KrasLA2 mouse model of lung cancer
Alterations in DNA copy number contribute to the development and progression of cancers and are common in epithelial tumors. We have used array Comparative Genomic Hybridization (aCGH) to visualize DNA copy number alterations across the genomes of lung tumors in the KrasLA2 model of lung cancer. C...
ORGANISM(S): Mus musculus 
2011-11-22 | E-GEOD-29230 | biostudies-arrayexpress
TranscriptomicsRNA-seq to investigate impact of treatment of KRAS mutant A549 lung adenocarcinoma cells with the multi-ERBB inhibitor Neratinib
KRAS mutation is widely presumed to confer independence from upstream RTK signalling, however emerging evidence from mouse models of lung cancer suggests that ERBB RTKs may amplify signalling through RAS isoforms and participate in mutant RAS-driven lung cancer. This is one of 3 datasets where we e...
ORGANISM(S): Homo sapiens 
2018-06-01 | E-MTAB-6483 | biostudies-arrayexpress
TranscriptomicsRNA-seq to investigate impact of treatment of KRAS mutant NCI-H2009 lung adenocarcinoma cells with the multi-ERBB inhibitor Neratinib
KRAS mutation is widely presumed to confer independence from upstream RTK signalling, however emerging evidence from mouse models of lung cancer suggests that ERBB RTKs may amplify signalling through RAS isoforms and participate in mutant RAS-driven lung cancer. This is one of 3 datasets where we e...
ORGANISM(S): Homo sapiens 
2018-06-01 | E-MTAB-6486 | biostudies-arrayexpress
TranscriptomicsRNA-seq to investigate impact of treatment of KRAS mutant NCI-H358 lung adenocarcinoma cells with the multi-ERBB inhibitor Neratinib
KRAS mutation is widely presumed to confer independence from upstream RTK signalling, however emerging evidence from mouse models of lung cancer suggests that ERBB RTKs may amplify signalling through RAS isoforms and participate in mutant RAS-driven lung cancer. This is one of 3 datasets where we e...
ORGANISM(S): Homo sapiens 
2018-06-01 | E-MTAB-6485 | biostudies-arrayexpress
GenomicsEpigenomic profiling of Non-small-cell Lung Cancer (NSCLC) cells with or without Eed
Polycomb repressive complexes (PRC) are frequently implicated in human cancer acting either as oncogenes or tumor suppressors. Here we show that PRC2 is a critical regulator of Kras-driven non-small-cell lung cancer (NSCLC) progression. Modulation of PRC2 by either Ezh2 overexpression or Eed deletio...
ORGANISM(S): Homo sapiens 
2016-01-15 | E-GEOD-61190 | biostudies-arrayexpress
TranscriptomicsProgression of KRas^G12D;Rosa26-MYC tumours to invasive disease
The aim of the study was to investigate gene expression tumour progression of KRas*/MYC driven lung tumours from adenocarcinoma in situ to invasive disease.
ORGANISM(S): Mus musculus 
2018-06-01 | E-MTAB-6432 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq
We sequenced mRNA from individual stormal cells (Macrophages, Monocytes, and Neutrophils) and tumor epithelial cells from KrasG12dD; p53-/- murine lung cancer model and WT control mouse to compare gene expressio profiles of lung cancer stroma and tumor cells to their counterparts of WT lugns. The tu...
ORGANISM(S): Mus musculus 
2015-03-06 | E-GEOD-59831 | biostudies-arrayexpress
TranscriptomicsExpression profiling of lung adenocarcinoma TPC tumor cells in Kras-driven NSCLC mouse model
Sustained tumor progression has been attributed to a distinct population of tumor-propagating cells (TPCs). To identify TPCs relevant to lung cancer pathogenesis, we investigated functional heterogeneity in tumor cells isolated from Kras-driven mouse models of non-small cell lung cancer (NSCLC). CD...
ORGANISM(S): Mus musculus 
2013-07-08 | E-GEOD-46439 | biostudies-arrayexpress
TranscriptomicsLKB1 modulates lung cancer differentiation and metastasis
Inherited mutation in LKB1 results in the Peutz-Jeghers syndrome (PJS), characterized by intestinal hamartomas and a modestly increased frequency of gastrointestinal and breast cancer1. Somatic inactivation of LKB1 occurs in human lung adenocarcinoma2-4, but its tumor suppressor role in this tissue ...
ORGANISM(S): Homo sapiens 
2007-08-28 | E-GEOD-6135 | biostudies-arrayexpress
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