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ProteomicsCharacterization of receptor-associated protein complex assembly in Interleukin (IL)-2- and IL-15-activated T-lymphocytes
Despite extensive investigation, it remains a paradox that IL-2 and IL-15 can differentially modulate the immune response using the same signaling receptors. In our previous work, we dissected the phosphotyrosine-driven signaling cascades triggered by both cytokines in Kit225 T-cells unveiling subtl...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080850 | MassIVE
ProteomicsNuclear phosphoproteomics analysis of resting and IL-2-stimulated T lymphocytes
The aim of the present project was to study in detail the site-specific phosphorylation events occurring both in resting as well as in T lymphocytes stimulated with IL-2 for five minutes. For that purpose we combined SILAC-based quantitative mass spectrometry analysis with phosphopeptide enrichment ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080773 | MassIVE
ProteomicsChanges in Gab2 phosphorylation and interaction partners in response to interleukin (IL)-2 stimulation in T-lymphocytes
Interleukin-2 (IL-2) stimulation results in T-cell growth as a consequence of activation of highly sophisticated and fine-tuned signaling pathways. Despite lacking intrinsic enzymatic activity, scaffold proteins such as Gab2, play a pivotal role in IL-2-triggered signal transduction integrating, div...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080707 | MassIVE
ProteomicsChanges in Gab2 phosphorylation and interaction partners in response to interleukin (IL)-2 stimulation in T-lymphocytes
Interleukin-2 (IL-2) stimulation results in T-cell growth as a consequence of activation of highly sophisticated and fine-tuned signaling pathways. Despite lacking intrinsic enzymatic activity, scaffold proteins such as Gab2, play a pivotal role in IL-2-triggered signal transduction integrating, div...
ORGANISM(S): Homo sapiens (Human) 
2016-04-11 | PXD003286 | Pride
Scaffold protein T-lymphocytes Phosphorylation Il-2 Gab2 Interactome 
ProteomicsPhosphoproteomic and functional approaches reveal changes in sperm-specific proteins downstream KOR in human spermatozoa
G-protein coupled receptors (GPCRs) belong to the seven transmembrane receptors superfamily that in response to external stimuli, transduce signals via G proteins to initiate different intracellular signaling pathways which culminate in specific cellular responses. Although in somatic cells the GPCR...
ORGANISM(S): Homo sapiens (Human) 
2019-01-11 | PXD011290 | Pride
Kor Human spermatozoa Phosphoproteomics 
ProteomicsCharacterization of receptor-associated protein complex assembly in Interleukin (IL)-2- and IL-15-activated T-lymphocytes
Despite extensive investigation, it remains a paradox that IL-2 and IL-15 can differentially modulate the immune response using the same signaling receptors. In our previous work, we dissected the phosphotyrosine-driven signaling cascades triggered by both cytokines in Kit225 T-cells unveiling subtl...
ORGANISM(S): Homo sapiens (Human) 
2016-08-08 | PXD002386 | Pride
Phosphorylation Il-2 Receptor complex assembly Il-15 Interactome 
ProteomicsNuclear phosphoproteomics analysis of resting and IL-2-stimulated T lymphocytes
The aim of the present project was to study in detail the site-specific phosphorylation events occurring both in resting as well as in T lymphocytes stimulated with IL-2 for five minutes. For that purpose we combined SILAC-based quantitative mass spectrometry analysis with phosphopeptide enrichment ...
ORGANISM(S): Homo sapiens (Human) 
2016-04-18 | PXD002839 | Pride
Phosphorylation T-lymphocyte Nucleus Il-2 
ProteomicsDissection of IL-2 and IL-15 signaling pathways
The aim of this study was to compare the signaling cascades initiated by the two closely related cytokines IL-2 and IL-15. Considering the relevance of protein tyrosine phosphorylation in signal transduction, in order to quantify changes in protein phosphorylation in response to IL-2 and IL-15, we c...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080767 | MassIVE
ProteomicsHs_HESC_Phospho_Silac_NCM_2r
hESCs cultured treated with nonconditioned medium (NCM) for 0min, 1hr or 24hr.
ORGANISM(S): Homo Sapiens (human) 
2011-12-31 | PAe005298 | PeptideAtlas
ProteomicsHs_HESC_Phospho_Silac_PMA_1r
hESCs cultured treated with PMA for 0min, 30min or 6hr
ORGANISM(S): Homo Sapiens (human) 
2011-12-31 | PAe005282 | PeptideAtlas
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