Sort   by:  
 Page size 
ProteomicsFrom LAL-D to MASLD: Insights into the role of LAL and Kupffer cells in liver inflammation and lipid metabolism
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent liver pathology worldwide, closely associated with obesity and metabolic disorders. Increasing evidence suggests that macrophages play a crucial role in the development of MASLD. Several human studies have shown an inver...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-01 | PXD056343 | Pride
Mouse Timstof pro 2 
UnknownFrom LAL-D to MASLD: Insights into the role of LAL and Kupffer cells in liver inflammation and lipid metabolism.
Not available
S-EPMC7618626 | biostudies-literature
UnknownLysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype.
Not available
S-EPMC5735906 | biostudies-literature
UnknownRecent insights into lysosomal acid lipase deficiency.
Not available
S-EPMC7614602 | biostudies-literature
ProteomicsPronounced metabolic alterations and susceptibility to inflammation, fibrosis, and cancer in livers from lysosomal acid lipase-deficient mice
Lysosomal acid lipase (LAL) is the sole lysosomal enzyme responsible for the degradation of cholesteryl esters and triacylglycerols at acidic pH. Impaired LAL activity leads to LAL deficiency (LAL-D), a severe and fatal disease characterized by ectopic lysosomal lipid accumulation. Reduced LAL activ...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD042478 | Pride
Lysosomal acid lipase (lal) Lal deficiency Liver Mouse Non-alcoholic fatty liver disease (nafld) 
UnknownN-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health.
Not available
S-EPMC6894082 | biostudies-literature
UnknownLimited Alleviation of Lysosomal Acid Lipase Deficiency by Deletion of Matrix Metalloproteinase 12.
Not available
S-EPMC11506919 | biostudies-literature
UnknownObservation of a novel double layer surface oxide phase on Ni3Al(111) at low temperature.
Not available
S-EPMC9418789 | biostudies-literature
ProteomicsRegional differences in the small intestinal proteome of control mice and of mice lacking lysosomal acid lipase
Background: Despite recent studies investigating the involvement of single cells in regional differences of the small intestine (SI), the metabolic contribution of the duodenum, jejunum, and ileum to the overall intestinal metabolism is still unclear. Basic procedures and main findings: Using an unt...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-20 | PXD048378 | Pride
Metabolism Proteomics Lal Small intestine Macrophages 
UnknownMetabolic changes and propensity for inflammation, fibrosis, and cancer in livers of mice lacking lysosomal acid lipase.
Not available
S-EPMC10482749 | biostudies-literature
Sort   by:  
 Page size