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TranscriptomicsExpression profiling, Lin-9 depletion array in D3 mES cells
Lin-9 was depleted in ES-D3 cells (ATCC CRL-1934) and the resulting expression profile changes mapped via microarrays
ORGANISM(S): Mus musculus 
2013-05-13 | E-MTAB-1490 | biostudies-arrayexpress
ProteomicsProline hydroxylation of ChREBP
This project investigated proline hydroxylation of ChREBP. Proline hydroxylation was investigated in flag-IP enriched protein extracts from ChREBP-flag overexpressing HEK293 cells (A) and in ChREBP-IP enriched mouse liver protein (male, C57BL6/J) (B).
ORGANISM(S): Mus musculus (Mouse) 
2020-10-19 | PXD019137 | Pride
Hek293 Mouse liver Proline hydroxylation 
no omics definedTranscription profiling time series of mouse melanocytes transfected with an inducible version of the oncogenic receptor Xmrk, starved for 72 h and afterwards stimulated with EGF
Signaling pathways specifically induced by the oncogenic receptor Xmrk can be elucidated by comparing gene expression in cells with the activated receptor to gene expression in cells with the non-activated receptor. Mouse melanocytes transfected with an inducible version of the oncogenic receptor Xm...
ORGANISM(S): Mus musculus 
2008-08-31 | E-MEXP-1311 | biostudies-arrayexpress
TranscriptomicsGLI1 knock-down in Panc1 cells
Panc1 (human pancreatic adenocarcinoma cells) cells were transfected with control siRNA (targeting firefly luciferase, siLuc) or siRNA targeting GLI1 (siGLI1, Pool of four siRNAs). 72h following transfection, RNA was prepared for array analysis.
ORGANISM(S): Homo sapiens 
2012-03-31 | E-MEXP-3379 | biostudies-arrayexpress
TranscriptomicsGenome-wide Analysis of Sp2 Occupancy and Expression Profiling Establish Sp2 as a Sequence-specific Transcription Factor Regulating Fundamental Cellular Processes - Expression Profiling
Mouse embyronic fibroblasts (MEFs) were depleted for transcription factor Specificity Factor 2 (Sp2) via Cre-Recombinase, harvested either 7 days or several weeks post infection and their expression profile compared to mock-infected MEFs.
ORGANISM(S): Mus musculus 
2012-05-24 | E-MTAB-1015 | biostudies-arrayexpress
TranscriptomicsUse of an activated beta-catenin to identify Wnt/beta-catenin pathway target genes in C. elegans, including a subset of collagen genes expressed in late larval development
The Wnt signaling pathway plays a fundamental role during the development of metazoans, where it functions in the regulation of diverse processes including cell fate specification, cell migration, and stem cell renewal. Activation of the beta-catenin dependent or canonical Wnt signaling pathway upr...
ORGANISM(S): Caenorhabditis elegans 
2014-05-13 | E-GEOD-51502 | biostudies-arrayexpress
Unknownc-Abl, Lamellipodin, and Ena/VASP proteins cooperate in dorsal ruffling of fibroblasts and axonal morphogenesis.
Not available
S-EPMC2946563 | biostudies-literature
no omics definedTranscription profiling of mouse 6780 cell line derived from murine T-cell lymphomaTGFbeta dependent gene expression in T-cell lymphomas
The cell line "6780" derived from murine T-cell lymphoma was grown in RPMI medium 1640 with 10% FBS/1% penicillin/Streptomycin/1% l-glutamine/50 μM 2-mercaptoethanol. Vector constructs containing a dominant negative mutant of the human TGF-beta receptor type II (pMSCV-TGFBR-IRES-GFP) or an empty ve...
ORGANISM(S): Mus musculus 
2010-01-01 | E-MEXP-2233 | biostudies-arrayexpress
TranscriptomicsMixed-polarization phenotype of ascites-associated macrophagesin human ovarian carcinoma: correlation of CD163 expression, cytokine levels and early relapse
Ascites-associated macrophages were collected from human ovarian carcinoma patients and their expression profiles determined via Agilent microarrays. In addition, monocyte derived macrophages from healthy donors were differentiated ex-vivo with MCSF and GMCSF and their expression profiles determined...
ORGANISM(S): Homo sapiens 
2014-03-07 | E-MTAB-1661 | biostudies-arrayexpress
UnknownDrosophila pico and its mammalian ortholog lamellipodin activate serum response factor and promote cell proliferation.
Not available
S-EPMC2691947 | biostudies-literature
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