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ProteomicsAnalysis of skeletal muscle from a tailored pig model of Duchenne muscular dystrophy
We recently generated a novel genetically engineered pig model displaying the fundamental biochemical, clinical and pathological hallmarks of human DMD. To get insight into the hierarchy of molecular derangements during progression of muscular dystrophy, we performed a label free proteome analysis o...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2016-09-27 | PXD002918 | Pride
Model organism Dmd Pig Muscle Lc-ms/ms 
ProteomicsProteome analysis of skeletal muscle samples from a porcine model of Duchenne muscular dystrophy treated by somatic gene editing
Duchenne muscular dystrophy (DMD) is caused by genetic deficiency of dystrophin and characterized by massive structural and functional changes of skeletal muscle tissue, leading to terminal muscle failure. In this project, proteomics data from skeletal muscle of a genetically engineered DMD pig mode...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2020-02-05 | PXD014893 | Pride
Porcine model Duchenne muscular dystrophy Somatic gene editing 
TranscriptomicsUpregulation of immunoproteasome subunits in myositis indicates active inflammation with involvement of antigen presenting cells, CD8 T-cells and IFNM-NM-3
Objective: In idiopathic inflammatory myopathies (IIM) infiltration of immune cells into muscle and upregulation of MHC-I expression implies increased antigen presentation and involvement of the proteasome system. To decipher the role of immunoproteasomes in myositis, we investigated individual cell...
ORGANISM(S): Homo sapiens 
2014-06-04 | E-GEOD-58173 | biostudies-arrayexpress
UnknownSpread of Terbinafine-Resistant Trichophyton mentagrophytes Type VIII (India) in Germany-"The Tip of the Iceberg?"
Not available
S-EPMC7712673 | biostudies-literature
ProteomicsA scalable, clinically severe pig model for Duchenne muscular dystrophy
Large animal models for Duchenne muscular dystrophy (DMD) are indispensible for preclinical evaluation of novel diagnostic procedures and treatment strategies. To evaluate functional consequences of Duchenne muscular dystrophy (DMD) in skeletal muscle and myocardium, we used a new genetically engine...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2021-12-01 | PXD027772 | Pride
Proteomics Dmd Duchenne muscular dystrophy Pig Animal model 
ProteomicsInositol signaling in the basidiomycete fungus Schizophyllum commune
Intracellular signaling is conserved in eukaryotes to allow for response to extracellular signals and to regulate development and cellular functions. In fungi, inositol phosphate signaling has been shown to be involved in growth, sexual reproduction, and metabolic adaptation lacking, however, report...
ORGANISM(S): Schizophyllum commune H4-8 
2021-07-01 | PXD026465 | Pride
Inositol monophosphatase Cell wall integrity Intracellular trafficking Heavy metals Sexual development Inositol phosphate signaling 
TranscriptomicsTranscription profiling of C. elegans embryonic muscle
Background: ; The force generating mechanism of muscle is evolutionarily ancient; the fundamental structural and functional components of the sarcomere are common to motile animals throughout phylogeny. Recent evidence suggests that the transcription factors that regulate muscle development are also...
ORGANISM(S): Caenorhabditis elegans 
2008-06-16 | E-GEOD-8231 | biostudies-arrayexpress
UnknownLocal Control after Locally Ablative, Image-Guided Radiotherapy of Oligometastases Identified by Gallium-68-PSMA-Positron Emission Tomography in Castration-Sensitive Prostate Cancer Patients (OLI-P).
Not available
S-EPMC9100669 | biostudies-literature
UnknownCommunicable diseases prioritized for surveillance and epidemiological research: results of a standardized prioritization procedure in Germany, 2011.
Not available
S-EPMC3186774 | biostudies-literature
UnknownGeographic disparities in access to outpatient stroke rehabilitation in Texas
Not available
S-EPMC12342321 | biostudies-literature
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