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ProteomicsMitochondrial regulation of the 26S proteasome
The proteasome is the main proteolytic system for targeted protein degradation in the cell. Its function is fine-tuned according to cellular needs. Inhibition of the respiratory chain impairs proteasome activity, regulation of proteasome function by mitochondrial metabolism, however, is unknown. He...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-18 | PXD019697 | Pride
26s proteasome Respiratory complex i Mitochondria Proteasome assembly factors Pyruvate Metabolic reprogramming Aspartate 
TranscriptomicsExpression data from mouse kidney tissue
The role of the renin-angiotensin system in chronic kidney disease involves multiple peptides and receptors. Exerting antipodal pathophysiological mechanisms, renin inhibition and AT1 antagonism ameliorate renal damage. This is a comparison between the renin inhibitor aliskiren with the At1 antagoni...
ORGANISM(S): Mus musculus 
2012-11-05 | E-GEOD-34552 | biostudies-arrayexpress
TranscriptomicsDifferential expression under hypoxia in zebrafish
The local background was subtracted from the fluorescent value of each spot. Feature intensities were extracted from scanned microarray images using GenePix Pro 5.1. (Axon Instruments). The images were visually inspected, and spots from low-quality areas of the array were flagged and excluded from f...
ORGANISM(S): Danio rerio 
2010-05-27 | E-GEOD-2069 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Mesenchymal Stem Cells (MSC) vs reference RNA of non-multipotent human fibroblasts HS68
Mesenchymal stem cells (MSC) resemble a multipotent adult stem cell population capable of differentiation into a number of different mesodermal cell types including adipodytes, osteoblasts, chondroblasts. Although still in debate there is some evidence, that these cells can also differentiate into c...
ORGANISM(S): Homo sapiens 
2005-08-23 | E-EMBL-4 | biostudies-arrayexpress
MetabolomicsGC-MS based targeted metabolic profiling identifies changes in the wheat metabolome following deoxynivalenol treatment
Fusarium graminearum and related species commonly infest grains causing the devastating plant disease Fusarium head blight (FHB) and the formation of trichothecene mycotoxins. The most relevant toxin is deoxynivalenol (DON), which acts as a virulence factor of the pathogen. FHB is difficult to contr...
2014-10-17 | MTBLS112 | MetaboLights
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