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UnknownEvaluation of protein A gene polymorphic region DNA sequencing for typing of Staphylococcus aureus strains.
Three hundred and twenty isolates of Staphylococcus aureus were typed by DNA sequence analysis of the X region of the protein A gene (spa). spa typing was compared to both phenotypic and molecular techniques for the ability to differentiate and categorize S. aureus strains into groups that correlate...
S-EPMC85690 | biostudies-literature
UnknownMulticenter Genomic Analysis of Carbapenem-Resistant Klebsiella pneumoniae from Bacteremia in China.
Klebsiella pneumoniae is one of the most common Gram-negative bacilli isolated from bloodstream infections worldwide, and recently an increased rate of carbapenem resistance has been reported in this pathogen. This study aims to describe the genomic characteristics of carbapenem-resistant K. pneumon...
S-EPMC9045280 | biostudies-literature
UnknownEmergence of Multiple SARS-CoV-2 Antibody Escape Variants in an Immunocompromised Host Undergoing Convalescent Plasma Treatment.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs), harboring spike protein N-terminal domain (NTD) or receptor-binding domain (RBD) mutations, exhibit reduced in vitro susceptibility to convalescent-phase serum, commercial antibody cocktails, and vaccine ...
S-EPMC8386433 | biostudies-literature
UnknownKlebsiella pneumoniae ST307 with OXA-181: threat of a high-risk clone and promiscuous plasmid in a resource-constrained healthcare setting.

Introduction

Klebsiella pneumoniae with OXA-48-like enzymes were introduced into Tshwane Tertiary Hospital (TTH) (Pretoria, South Africa) during September 2015, causing nosocomial outbreaks.

Methods

PCR methodologies and WGS were used to characterize K. pneumoniae with carbapenemases ...
S-EPMC7069492 | biostudies-literature
UnknownAcquisition of genomic elements were pivotal for the success of Escherichia coli ST410.

Background

Escherichia coli ST410 is an emerging MDR clone linked to blaCTX-M-15 and blaOXA-181. Limited comprehensive data about the global distribution of ST410 clades and mobile genetic elements associated with different β-lactamases are available.

Methods

Short- and long-read WGS ...
S-EPMC10205468 | biostudies-literature
UnknownGenomic Epidemiology and Serology Associated with a SARS-CoV-2 R.1 Variant Outbreak in New Jersey.
Examining the neutralizing capacity of monoclonal antibodies (MAbs) used to treat COVID-19, as well as antibodies recovered from unvaccinated, previously vaccinated, and infected individuals, against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) remains crit...
S-EPMC9600516 | biostudies-literature
UnknownGrowth-inhibitory activity of natural and synthetic isothiocyanates against representative human microbial pathogens.

Aims

The aim of this study was to test the growth inhibition activity of isothiocyanates (ITCs), defence compounds of plants, against common human microbial pathogens.

Methods and results

In this study, we have tested the growth-inhibitory activity of a diverse collection of new and p...
S-EPMC3787980 | biostudies-literature
UnknownDiverse enterotoxin gene profiles among clonal complexes of Staphylococcus aureus isolates from the Bronx, New York.
Staphylococcal enterotoxins (SE) can cause toxin-mediated disease, and those that function as superantigens are implicated in the pathogenesis of allergic diseases. The prevalence of 19 enterotoxin genes was determined by PCR in clinical S. aureus strains derived from wounds (108) and blood (99). We...
S-EPMC2772442 | biostudies-literature
UnknownMolecular genetics of para-aminosalicylic acid resistance in clinical isolates and spontaneous mutants of Mycobacterium tuberculosis.
The emergence of Mycobacterium tuberculosis resistant to first-line antibiotics has renewed interest in second-line antitubercular agents. Here, we aimed to extend our understanding of the mechanisms underlying para-aminosalicylic acid (PAS) resistance by analysis of six genes of the folate metaboli...
S-EPMC2681553 | biostudies-literature
UnknownNaturally occurring IgG antibody levels to the Staphylococcus aureus protein IsdB in humans.
Staphylococcus aureus is a well-recognized, clinically important cause of nosocomial infections, and as such, a vaccine to prevent S. aureus infections would be an important achievement. A Phase IIB/III study of V710, a vaccine containing iron-regulated surface determinant B (IsdB), demonstrated sig...
S-EPMC3906349 | biostudies-literature
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