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ProteomicsMapping the complexity of ME/CFS: Evidence for abnormal energy metabolism, altered immune profile and vascular dysfunction
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disorder with no known underlying mechanisms, diagnostic tools, or treatments. Multiple areas of dysfunction have been extensively studied, but rarely examined together. We recruited age- and sex-matched ME/CFS patients and he...
ORGANISM(S): Homo sapiens (Human) 
2025-11-14 | PXD068504 | Pride
Metabolomics Immune dysfunction Energy metabolism Myalgic encephalomyelitis/chronic fatigue syndrome 
ProteomicsRecombinant Protein Spectral Library (rPSL) DIA-MS Method Improves Identification and Quantification of Low-Abundance Cancer-Associated and Kynurenine Pathway Proteins
Data-independent acquisition mass spectrometry (DIA-MS) is a powerful tool for quantitative proteomics, but a well-constructed reference spectral library is crucial to optimize DIA analysis, particularly for low-abundance proteins. In this study, we evaluate the efficacy of a recombinant protein spe...
ORGANISM(S): Homo sapiens (Human) 
2025-05-15 | PXD061696 | Pride
Snap frozen tissues Rpsl Dia-ms Cancer- associated proteins Cell lysates Kynurenine pathway proteins Recombinant protein spectral library 
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