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TranscriptomicsThe 5p12 breast cancer susceptibility locus affects MRPS30 expression in estrogen-receptor positive tumors
Uninvolved tissue taken at the time of primary surgical resection of an adenocarcinoma. Uninvolved status determined by surgical margin and gross appearance, not pathology 35 biologically distinct samples, no replicates, no controls
ORGANISM(S): Homo sapiens 
2014-05-22 | E-GEOD-48067 | biostudies-arrayexpress
TranscriptomicsIntegrative analysis reveals extensive association between microRNA expression and mRNA-protein translation [mRNA]
Transcription signatures have been used to stratify breast cancer patients into clinically distinct subgroups. However, transcription alone does not determine protein expression. Of potentially equal importance for determining the tumor phenotype is the rate at which transcripts are translated to fo...
ORGANISM(S): Homo sapiens 
2015-02-02 | E-GEOD-58212 | biostudies-arrayexpress
TranscriptomicsAge and estrogen-dependent inflammation in breast adenocarcinoma and normal breast tissue [cohort_1]
Chronic inflammation promotes breast tumor growth and invasion by accelerating angiogenesis and tissue remodeling in the tumor microenvironment. The relationship between inflammation and estrogen, which drives the growth of 70 percent of breast tumors, is complex. Low levels of estrogen exposure st...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-70905 | biostudies-arrayexpress
TranscriptomicsAge and estrogen-dependent inflammation in breast adenocarcinoma and normal breast tissue [cohort_2]
Chronic inflammation promotes breast tumor growth and invasion by accelerating angiogenesis and tissue remodeling in the tumor microenvironment. The relationship between inflammation and estrogen, which drives the growth of 70 percent of breast tumors, is complex. Low levels of estrogen exposure st...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-70947 | biostudies-arrayexpress
UnknownIntegrative analysis reveals extensive association between microRNA expression and mRNA-protein translation [mRNA]
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-58212 | biostudies-other
TranscriptomicsIntegrative analysis reveals extensive association between microRNA expression and mRNA-protein translation [miRNA]
Transcription signatures have been used to stratify breast cancer patients into clinically distinct subgroups. However, transcription alone does not determine protein expression. Of potentially equal importance for determining the tumor phenotype is the rate at which transcripts are translated to fo...
ORGANISM(S): Homo sapiens 
2015-02-02 | E-GEOD-58210 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of patients from the Danish Center for Translational Breast Cancer Research program
Female breast cancer patients who underwent surgery for breast cancer as part of the Danish Center for Translational Breast Cancer Research program were included from 2003 to 2012. Patient inclusion criteria were: (1) a unifocal tumor with an estimated size of more than 20 mm in diameter, (2) none o...
ORGANISM(S): Homo sapiens 
2018-11-16 | E-MTAB-7201 | biostudies-arrayexpress
TranscriptomicsMolecular Characterization of Breast Cancer Subtypes from Joint Analysis of High Throughput miRNA and mRNA Data (II)
MicroRNAs (miRNAs) are a class of short, single-stranded widely expressed noncoding RNAs that regulate the stability or translational efficiency of target messenger RNAs. Date derived from expression profiling of 489 miRNAs in 101 human primary breast tumor samples, along with genome-wide matched mR...
ORGANISM(S): Homo sapiens 
2010-12-01 | E-GEOD-19783 | biostudies-arrayexpress
TranscriptomicsMolecular Characterization of Breast Cancer Subtypes Derived from Joint Analysis of High Throughput miRNA and mRNA Data
MicroRNAs (miRNAs) are a class of short, single-stranded widely expressed noncoding RNAs that regulate the stability or translational efficiency of target messenger RNAs. Date derived from expression profiling of 489 miRNAs in 101 human primary breast tumor samples, along with genome-wide matched mR...
ORGANISM(S): Homo sapiens 
2010-12-01 | E-GEOD-19536 | biostudies-arrayexpress
TranscriptomicsIndividual and combined effects of DNA methylation and copy number alterations on miRNA expression in breast tumors
Background: The global effect of copy number and epigenetic alterations on miRNA expression in cancer is poorly understood. In the present study, we integrate genome-wide copy number, DNA methylation and miRNA expression and identify genetic mechanisms underlying miRNA dysregulation in breast cancer...
ORGANISM(S): Homo sapiens 
2013-10-24 | E-GEOD-46934 | biostudies-arrayexpress
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